Novel 2-Arylbenzimidazole derivatives as multi-targeting agents to treat Alzheimer’s disease
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DOI: 10.1007/s00044-017-1874-1
Abstract: This study describes the synthesis, pharmacological evaluation, including acetylcholinesterase (AChE)/butyrylcholinesterase (BChE) inhibition, amyloid beta (Aβ) antiaggregation, and neuroprotective effects, as well as molecular modeling of novel 2-(4-substituted phenyl)-1H-benzimidazole derivatives. These derivatives were synthesized by cyclization… read more here.
Keywords: arylbenzimidazole derivatives; alzheimer disease; novel arylbenzimidazole; bche ... See more keywords