A novel assay provides sensitive measurement of physiologically relevant changes in albumin permeability in isolated human and rodent glomeruli
Sign Up to like & getrecommendations! Published in 2018 at "Kidney International"
DOI: 10.1016/j.kint.2017.12.003
Abstract: Increased urinary albumin excretion is a key feature of glomerular disease but has limitations as a measure of glomerular permeability. Here we describe a novel assay to measure the apparent albumin permeability of single capillaries… read more here.
Keywords: novel assay; albumin permeability; rodent glomeruli; permeability ... See more keywords
A Novel Assay for RNA Polymerase I Transcription Elongation Sheds Light on the Evolutionary Divergence of Eukaryotic RNA Polymerases.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemistry"
DOI: 10.1021/acs.biochem.8b01256
Abstract: Eukaryotic cells express at least three nuclear RNA polymerases (Pols), each with a unique set of gene targets. Though these enzymes are homologous, there are many differences among the Pols. In this study, a novel… read more here.
Keywords: novel assay; elongation; transcription elongation; rate ... See more keywords
Validation of a Novel Assay to Distinguish Bacterial and Viral Infections
Sign Up to like & getrecommendations! Published in 2017 at "Pediatrics"
DOI: 10.1542/peds.2016-3453
Abstract: A novel 3-protein host-assay’s diagnostic performance for distinguishing between bacterial and viral etiologies is validated in a double-blind, investigator-driven study in febrile children. BACKGROUND: Reliably distinguishing bacterial from viral infections is often challenging, leading to… read more here.
Keywords: validation novel; novel assay; viral infections; assay distinguish ... See more keywords
Novel Assay Platform to Evaluate Intracellular Killing of Mycobacterium tuberculosis: In Vitro and In Vivo Validation
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.750496
Abstract: One of the main hallmarks of tuberculosis (TB) is the ability of the causative agent to transform into a stage of dormancy and the capability of long persistence in the host phagocytes. It is believed… read more here.
Keywords: mycobacterium tuberculosis; assay platform; novel assay; intracellular killing ... See more keywords
Development of a Novel Assay Based on Plant-Produced Infectious Bursal Disease Virus VP3 for the Differentiation of Infected From Vaccinated Animals
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2021.786871
Abstract: Infectious bursal disease virus is the causative agent of Gumboro disease, a severe infection that affects young chickens and is associated with lymphoid depletion in the bursa of Fabricius. Traditional containment strategies are based either… read more here.
Keywords: vp3; development novel; disease; novel assay ... See more keywords
Quantification of oxalate by novel LC-MS/MS: assay development, validation and application in lumasiran clinical trials.
Sign Up to like & getrecommendations! Published in 2023 at "Bioanalysis"
DOI: 10.4155/bio-2022-0227
Abstract: Background: Measurement of plasma oxalate (POx) is challenging, but critical, for management of patients with primary hyperoxaluria type 1. A novel LC-MS/MS assay was developed, validated and used to quantify POx in patients with primary hyperoxaluria… read more here.
Keywords: development validation; quantification oxalate; quantification; novel assay ... See more keywords