Novel Aurora A and Protein Kinase C (α, β1, β2, and θ) Multitarget Inhibitors: Impact of Selenium Atoms on the Potency and Selectivity.
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DOI: 10.1021/acs.jmedchem.1c01031
Abstract: Aurora kinases and protein kinase C (PKC) have been shown to be involved in different aspects of cancer progression. To date, no dual Aurora/PKC inhibitor with clinical efficacy and low toxicity is available. Here, we… read more here.
Keywords: selenium; protein kinase; novel aurora; selectivity ... See more keywords