A novel autophagy modulator 6-Bio ameliorates SNCA/α-synuclein toxicity
Sign Up to like & getrecommendations! Published in 2017 at "Autophagy"
DOI: 10.1080/15548627.2017.1302045
Abstract: ABSTRACT Parkinson disease (PD) is a life-threatening neurodegenerative movement disorder with unmet therapeutic intervention. We have identified a small molecule autophagy modulator, 6-Bio that shows clearance of toxic SNCA/α-synuclein (a protein implicated in synucleopathies) aggregates… read more here.
Keywords: modulator bio; snca synuclein; novel autophagy; bio ... See more keywords
Abstract 452: Novel autophagy inhibitory strategies to overcome chemotherapy resistance in multiple myeloma
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-452
Abstract: Multiple myeloma (MM) is an incurable disease. Classical chemotherapeutics including bortezomib, melphalan, lenalidomide and thalidomide have greatly enhanced survival times. Unfortunately, patients typically relapse and become refractory with an average survival of 5 years post-diagnosis.… read more here.
Keywords: novel autophagy; disease; resistance; multiple myeloma ... See more keywords
Abstract IA08: Pooled CRISPR screens for novel autophagy-related factors identify TMEM41, an ER-resident protein predicted to be a channel
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Cancer Research"
DOI: 10.1158/1557-3125.pi3k-mtor18-ia08
Abstract: The power of forward genetics in yeast is the foundation on which the field of autophagy research firmly stands. Complementary work on autophagy in metazoans has revealed both the deep conservation of this process, as… read more here.
Keywords: crispr screens; crispr; screens novel; novel autophagy ... See more keywords
Identification and validation of P4HB as a novel autophagy-related biomarker in diabetic nephropathy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.965816
Abstract: Diabetic nephropathy (DN), a frequent microvascular complication of diabetes, has been recognized as a primary cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD). Previous studies found that autophagy of renal tubular epithelial… read more here.
Keywords: novel autophagy; p4hb; related biomarker; autophagy related ... See more keywords
Repositioning of the β-Blocker Carvedilol as a Novel Autophagy Inducer That Inhibits the NLRP3 Inflammasome
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.01920
Abstract: The NLRP3 inflammasome is a multiprotein complex that plays a key role in the innate immune system, and aberrant activation of this complex is involved in the pathogenesis of inflammatory diseases. Carvedilol (CVL) is an… read more here.
Keywords: inducer inhibits; novel autophagy; cvl; inhibits nlrp3 ... See more keywords
Trends and recent progresses of selenium nanoparticles as novel autophagy regulators for therapeutic development
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Nutrition"
DOI: 10.3389/fnut.2023.1116051
Abstract: Autophagy, one of the major intracellular degradation systems, plays an important role in maintaining normal cellular physiological functions and protecting organisms from different diseases. Selenium (Se), an essential trace element, is involved in many metabolic… read more here.
Keywords: autophagy regulators; novel autophagy; development; trends recent ... See more keywords