A novel bacterial carboxylesterase identified in a metagenome derived-clone from Brazilian mangrove sediments
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Biology Reports"
DOI: 10.1007/s11033-020-05484-6
Abstract: A functional screening of 1152 clones from a plasmid library constructed with DNA extracted from Brazilian mangrove sediments revealed 3 positive clones for ester-hydrolyzing enzymes, or about one lipolytic gene per 1.2 Mb DNA, which corroborates… read more here.
Keywords: novel bacterial; bacterial carboxylesterase; mangrove sediments; brazilian mangrove ... See more keywords
BC-MOS: The novel bacterial cellulose based MOS gas sensors
Sign Up to like & getrecommendations! Published in 2019 at "Materials Letters"
DOI: 10.1016/j.matlet.2018.11.011
Abstract: Abstract Recently a high interest has grown around the use of organic materials, as cellulose, in engineering and electronic fields due to the possibility to create hybrid devices. The objective of this work was to… read more here.
Keywords: mos novel; bacterial cellulose; novel bacterial; gas sensors ... See more keywords
Two Decades of Successful SAR-Grounded Stories of the Novel Bacterial Topoisomerase Inhibitors (NBTIs)
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.9b01738
Abstract: The emergence of bacterial resistance against life-saving medicines has forced the scientific community and pharmaceutical industry to take actions in the quest for novel antibacterials. These should not only overcome the existing bacterial resistance but… read more here.
Keywords: novel bacterial; topoisomerase inhibitors; topoisomerase; inhibitors nbtis ... See more keywords
1,3-Dioxane-Linked Novel Bacterial Topoisomerase Inhibitors: Expanding Structural Diversity and the Antibacterial Spectrum.
Sign Up to like & getrecommendations! Published in 2022 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.2c00111
Abstract: Antibacterial resistance continues its devastation of available therapies. Novel bacterial topoisomerase inhibitors (NBTIs) offer one solution to this critical issue. Two series of amine NBTIs bearing tricyclic DNA-binding moieties as well as amide NBTIs with… read more here.
Keywords: bacterial topoisomerase; novel bacterial; dioxane linked; topoisomerase inhibitors ... See more keywords
Antimicrobial properties of the novel bacterial isolate Paenibacilllus sp. SMB1 from a halo-alkaline lake in India
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-47879-x
Abstract: Antibiotic-resistance is ever growing burden on our society for the past many years. Many synthetic chemistry approaches and rational drug-design have been unable to pace up and tackle this problem. Natural resources, more specifically, the… read more here.
Keywords: novel bacterial; bacterial isolate; properties novel; lake india ... See more keywords
Identification of novel bacterial urease inhibitors through molecular shape and structure based virtual screening approaches
Sign Up to like & getrecommendations! Published in 2020 at "RSC Advances"
DOI: 10.1039/d0ra02363a
Abstract: The enzyme urease is an essential colonizing factor of the notorious carcinogenic pathogen Helicobacter pylori (H. pylori), conferring acid resistance to the bacterium. Recently, antibiotic resistant strains have emerged globally with little to no alternative… read more here.
Keywords: novel bacterial; shape; urease inhibitors; screening ... See more keywords
µProteInS - a proteogenomics pipeline for finding novel bacterial microproteins encoded by small ORFs
Sign Up to like & getrecommendations! Published in 2022 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btac115
Abstract: SUMMARY Genome annotation pipelines traditionally exclude Open Reading Frames shorter than 100 codons to avoid false identifications. However, studies have been showing that these may encode functional microproteins with meaningful biological roles. We developed µProteInS,… read more here.
Keywords: pipeline finding; novel bacterial; finding novel; pipeline ... See more keywords
Novel Bacterial Topoisomerase Inhibitors with Potent Broad-Spectrum Activity against Drug-Resistant Bacteria
Sign Up to like & getrecommendations! Published in 2017 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.02100-16
Abstract: ABSTRACT The novel bacterial topoisomerase inhibitor class is an investigational type of antibacterial inhibitor of DNA gyrase and topoisomerase IV that does not have cross-resistance with the quinolones. Here, we report the evaluation of the… read more here.
Keywords: novel bacterial; dna; topoisomerase; resistance ... See more keywords
Assembly of 97 Novel Bacterial Genomes in the Microbial Community Affiliated with Polyvinyl Alcohol in Soil of Northern China
Sign Up to like & getrecommendations! Published in 2022 at "BioMed Research International"
DOI: 10.1155/2022/2229147
Abstract: Background Undeveloped ecosystems belong to rich source of microbial population, of which resources remain unearthed. A kind of polymeric compound system with high polyvinyl alcohol (PVA) content has been reported and named Taisui. Marker gene… read more here.
Keywords: novel bacterial; bacterial genomes; pva; polyvinyl alcohol ... See more keywords
Assembly of hundreds of novel bacterial genomes from the chicken caecum
Sign Up to like & getrecommendations! Published in 2020 at "Genome Biology"
DOI: 10.1186/s13059-020-1947-1
Abstract: Background Chickens are a highly important source of protein for a large proportion of the human population. The caecal microbiota plays a crucial role in chicken nutrition through the production of short-chain fatty acids, nitrogen… read more here.
Keywords: novel bacterial; chicken caecum; bacterial genomes; genomes chicken ... See more keywords