Novel benzenesulfonamide‐thiouracil conjugates with a flexible N‐ethyl acetamide linker as selective CA IX and CA XII inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200434
Abstract: Novel benzenesulfonamide derivatives linked to diverse functionalized thiouracils through a flexible N‐ethyl acetamide linker were designed and synthesized as carbonic anhydrase (CA) inhibitors. The synthesized candidates demonstrated a potent inhibitory activity against four different CA… read more here.
Keywords: novel benzenesulfonamide; xii; acetamide linker; linker ... See more keywords
Synthesis of novel benzenesulfonamide bearing 1,2,3-triazole linked hydroxy-trifluoromethylpyrazolines and hydrazones as selective carbonic anhydrase isoforms IX and XII inhibitors.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.01.002
Abstract: A series of twenty four hydroxy-trifluoromethylpyrazoline-carbonyl-1,2,3-triazoles and four hydrazones bearing benzenesulfonamide moieties was obtained by condensation of carboxyhydrazides with substituted 1,3-diketones. All the newly synthesized compounds were investigated as inhibitors of physiologically and pharmacologically relevant… read more here.
Keywords: synthesis novel; benzenesulfonamide bearing; triazole linked; linked hydroxy ... See more keywords
Discovery of a Novel Benzenesulfonamide Analogue That Inhibits Proliferation and Metastasis Against Ovarian Cancer OVCAR-8 Cells
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DOI: 10.2147/dddt.s225201
Abstract: Background Ovarian cancer has been a salient public health concern in the world. It is necessary to develop novel antitumor drugs to treat ovarian cancer. Purpose This study investigated the synthesis, antiproliferation ability, antitumor mechanisms… read more here.
Keywords: ovarian cancer; cancer ovcar; novel benzenesulfonamide; cancer ... See more keywords