Discovery of novel N-benzylbenzamide derivatives as tubulin polymerization inhibitors with potent antitumor activities.
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DOI: 10.1016/j.ejmech.2021.113316
Abstract: A series of novel N-benzylbenzamide derivatives were designed and synthesized as tubulin polymerization inhibitors. Among fifty-one target compounds, compound 20b exhibited significant antiproliferative activities with IC50 values ranging from 12 to 27 nM against several cancer… read more here.
Keywords: polymerization inhibitors; novel benzylbenzamide; tubulin polymerization; discovery novel ... See more keywords