Synthesis and discovery of potent carbonic anhydrase, acetylcholinesterase, butyrylcholinesterase, and α‐glycosidase enzymes inhibitors: The novel N,N′‐bis‐cyanomethylamine and alkoxymethylamine derivatives
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22042
Abstract: During this investigation, N,N′‐bis‐azidomethylamines, N,N′‐bis‐cyanomethylamine, new alkoxymethylamine and chiral derivatives, which are considered to be a new generation of multifunctional compounds, were synthesized, functional properties were investigated, and anticholinergic and antidiabetic properties of those compounds… read more here.
Keywords: carbonic anhydrase; novel bis; bis cyanomethylamine; alkoxymethylamine derivatives ... See more keywords
Facile synthesis of novel bis-derivatives of 2,5-diamino-thiadiazole/N,N′-thiocarbohydrazide and their biological perspective
Sign Up to like & getrecommendations! Published in 2018 at "Research on Chemical Intermediates"
DOI: 10.1007/s11164-018-3554-2
Abstract: A series of new bis derivatives of 2,5-thiadiazole and N,N′-thiocarbohydrazide along with their transition metal complexes were synthesized by green methods (sonochemical and microwave), i.e., energy and time efficient and operationally more simple than existing… read more here.
Keywords: synthesis novel; thiadiazole thiocarbohydrazide; facile synthesis; novel bis ... See more keywords
Synthesis, characterization, lipophilicity and cytotoxic properties of novel bis(carboxylato)oxalatobis(1-propylamine)platinum(IV) complexes
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DOI: 10.1016/j.ica.2019.03.036
Abstract: Abstract A series of novel bis(carboxylato)oxalatobis(1-propylamine)platinum(IV) complexes as well as an ethylamine analog were synthesized. The compounds are either symmetrical with both axial ligands consisting of monoesters of succinic acid, or unsymmetrical, with one axial… read more here.
Keywords: lipophilicity; bis carboxylato; spectroscopy; oxalatobis propylamine ... See more keywords
Novel bis-nitrile grafted [6]Helicenes through a photochemical pathway: Chiroptical and photophysical properties
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DOI: 10.1016/j.molstruc.2020.129087
Abstract: Abstract New suitably nitrile grafted [6]Helicene derivatives have been synthesized, in 36%-54% over all yields, through a UV-light photochemical pathway making use of inexpensive materials and mild experimental conditions. The target hexacylic helicenes have been… read more here.
Keywords: bis nitrile; photochemical pathway; helicenes photochemical; novel bis ... See more keywords
Synthesis of novel bis- and poly(aryldiazenylthiazoles)
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DOI: 10.1080/00397911.2019.1620283
Abstract: Abstract A novel series of bis- and poly(arydiazenyl)thiazoles were prepared in good yields by the reaction of the appropriate α-keto-hydrazonoyl chlorides with the corresponding bis- and poly(hydrazinecarbothioamide) in refluxing EtOH/DMF in the presence of few… read more here.
Keywords: synthesis novel; novel bis; bis; bis poly ... See more keywords
Synthesis and Biological Evaluation of Some Novel Bis-Thiadiazoles as Antimicrobial and Antitumor Agents
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DOI: 10.1080/10406638.2019.1709874
Abstract: Abstract A novel series of bis(1,3,4-thiadiazole) derivatives were synthesized as a sole product in one step methodology by reaction of bis-hydrazonoylchloride 3 with many of hydrazinecarbodithioate derivatives 2a–e, 6a,b, and 8a–e. We discuss the mechanisms… read more here.
Keywords: evaluation novel; bis thiadiazoles; biological evaluation; novel bis ... See more keywords
Novel Bis(1,2,4-oxadiazolyl) Fused Thiazole Derivatives: Synthesis and Anticancer Activity
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DOI: 10.1134/s107036321812023x
Abstract: A novel series of bis-1,2,4-oxadiazole fused benzothiazole derivatives 9a–9j are synthesized, and their structures are confirmed by 1H and 13C NMR, and mass spectral data. All products are evaluated in vitro for their anticancer potential… read more here.
Keywords: novel bis; anticancer activity; bis oxadiazolyl; anticancer ... See more keywords
Novel bis-amide-based bis-thiazoles as anti-colorectal cancer agents through Bcl-2 inhibition: Synthesis, In Vitro, and In Vivo studies.
Sign Up to like & getrecommendations! Published in 2022 at "Anti-cancer agents in medicinal chemistry"
DOI: 10.2174/1871520622666220615140239
Abstract: BACKGROUND Some heterocycles having bisamide linkage are receiving much interest due to their remarkable biological potencies and their naturally occurring. Some bisamides and thiazole derivatives were found to inhibit the protein levels of Bcl-2 significantly.… read more here.
Keywords: cell; inhibition; bis; colorectal cancer ... See more keywords
In Vitro Anticancer Properties of Novel Bis-Triazoles
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DOI: 10.3390/cimb45010014
Abstract: Here, we describe the anticancer activity of our novel bis-triazoles MS47 and MS49, developed previously as G-quadruplex stabilizers, focusing specifically upon the human melanoma MDA-MB-435 cell line. At the National Cancer Institute (NCI), USA, bis-triazole… read more here.
Keywords: cell; bis triazoles; melanoma; human melanoma ... See more keywords
Novel Bis- and Mono-Pyrrolo[2,3-d]pyrimidine and Purine Derivatives: Synthesis, Computational Analysis and Antiproliferative Evaluation
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DOI: 10.3390/molecules26113334
Abstract: Novel symmetrical bis-pyrrolo[2,3-d]pyrimidines and bis-purines and their monomers were synthesized and evaluated for their antiproliferative activity in human lung adenocarcinoma (A549), cervical carcinoma (HeLa), ductal pancreatic adenocarcinoma (CFPAC-1) and metastatic colorectal adenocarcinoma (SW620) cells. The… read more here.
Keywords: mono pyrrolo; novel bis; pyrimidine; bis ... See more keywords
Design and Synthesis of Novel Bis-Imidazolyl Phenyl Butadiyne Derivatives as HCV NS5A Inhibitors
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DOI: 10.3390/ph15050632
Abstract: In today’s global plan to completely eradicate hepatitis C virus (HCV), the essential list of medications used for HCV treatment are direct-acting antivirals (DAAs), as interferon-sparing regimens have become the standard-of-care (SOC) treatment. HCV nonstructural… read more here.
Keywords: design synthesis; ns5a inhibitors; imidazolyl phenyl; bis imidazolyl ... See more keywords