Characterization of a Novel Bispecific Antibody with Improved Conformational and Chemical Stability.
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DOI: 10.1016/j.xphs.2019.06.025
Abstract: Bispecific antibodies containing single chain variable fragment (scFv) appended to IgGs offer unique development challenges. Here we describe the stability of a novel bispecific format, BiS5, where the scFv is tethered to the CH3 domain.… read more here.
Keywords: scfv; stability; novel bispecific; chemical stability ... See more keywords