Novel candidate theranostic radiopharmaceutical based on strontium hexaferrite nanoparticles conjugated with azacrown ligand.
Sign Up to like & getrecommendations! Published in 2023 at "Dalton transactions"
DOI: 10.1039/d2dt03548k
Abstract: In this article, we report to the best of our knowledge the first modification of NPs with ligands for combined radiopharmaceuticals. Nanoparticles with suitable magnetic properties can be used both for diagnostics as a contrast… read more here.
Keywords: strontium hexaferrite; novel candidate; theranostic radiopharmaceutical; hexaferrite nanoparticles ... See more keywords
Novel Candidate Genes Underlying Extreme Trophic Specialization in Caribbean Pupfishes
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Biology and Evolution"
DOI: 10.1093/molbev/msw286
Abstract: The genetic changes responsible for evolutionary transitions from generalist to specialist phenotypes are poorly understood. Here we examine the genetic basis of craniofacial traits enabling novel trophic specialization in a sympatric radiation of Cyprinodon pupfishes… read more here.
Keywords: novel candidate; trophic specialization; candidate genes; genes underlying ... See more keywords
Reaffirmation of known major genes and the identification of novel candidate genes associated with carcass-related metrics based on whole genome sequence within a large multi-breed cattle population
Sign Up to like & getrecommendations! Published in 2019 at "BMC Genomics"
DOI: 10.1186/s12864-019-6071-9
Abstract: BackgroundThe high narrow sense heritability of carcass traits suggests that the underlying additive genetic potential of an individual should be strongly correlated with both animal carcass quality and quantity, and therefore, by extension, carcass value.… read more here.
Keywords: novel candidate; candidate; major genes; candidate genes ... See more keywords
A somatic mutation in PIK3CD unravels a novel candidate gene for lymphatic malformation
Sign Up to like & getrecommendations! Published in 2021 at "Orphanet Journal of Rare Diseases"
DOI: 10.1186/s13023-021-01782-9
Abstract: Background Lymphatic malformations (LMs) are benign congenital malformations that stem from the abnormal development of the lymphatic vessels during early embryogenesis. Somatic PIK3CA gene mutations are conventional cause leading to LMs. Both macrocystic and microcystic… read more here.
Keywords: pik3cd; novel candidate; candidate gene; gene ... See more keywords
Comparative analysis of Streptococcus suis genomes identifies novel candidate virulence-associated genes in North American isolates
Sign Up to like & getrecommendations! Published in 2022 at "Veterinary Research"
DOI: 10.1186/s13567-022-01039-8
Abstract: Streptococcus suis is a significant economic and welfare concern in the swine industry. Pan-genome analysis provides an in-silico approach for the discovery of genes involved in pathogenesis in bacterial pathogens. In this study, we performed… read more here.
Keywords: analysis; novel candidate; candidate virulence; streptococcus suis ... See more keywords
Novel candidate regulators and developmental trajectory of pituitary thyrotropes.
Sign Up to like & getrecommendations! Published in 2023 at "Endocrinology"
DOI: 10.1210/endocr/bqad076
Abstract: The pituitary gland regulates growth, metabolism, reproduction, the stress response, uterine contractions, lactation, and water retention. It secretes hormones in response to hypothalamic input, end organ feedback, and diurnal cues. The mechanisms by which pituitary… read more here.
Keywords: cell; candidate regulators; trajectory pituitary; novel candidate ... See more keywords
Exome Sequencing Identifies TENM4 as a Novel Candidate Gene for Schizophrenia in the SCZD2 Locus at 11q14-21
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2018.00725
Abstract: Schizophrenia is a complex psychiatric disorder with high genetic heterogeneity, however, the contribution of rare mutations to the disease etiology remains to be further elucidated. We herein performed exome sequencing in a Han Chinese schizophrenia… read more here.
Keywords: exome sequencing; schizophrenia; novel candidate; sczd2 locus ... See more keywords
Systematic In Vitro Evaluation of a Library of Approved and Pharmacologically Active Compounds for the Identification of Novel Candidate Drugs for KMT2A-Rearranged Leukemia
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.779859
Abstract: Patients whose leukemias harbor a rearrangement of the Mixed Lineage Leukemia (MLL/KMT2A) gene have a poor prognosis, especially when the disease strikes in infants. The poor clinical outcome linked to this aggressive disease and the… read more here.
Keywords: leukemia cell; novel candidate; leukemia; kmt2a leukemia ... See more keywords
Hooked Up from a Distance: Charting Genome-Wide Long-Range Interaction Maps in Neural Cells Chromatin to Identify Novel Candidate Genes for Neurodevelopmental Disorders
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24021164
Abstract: DNA sequence variants (single nucleotide polymorphisms or variants, SNPs/SNVs; copy number variants, CNVs) associated to neurodevelopmental disorders (NDD) and traits often map on putative transcriptional regulatory elements, including, in particular, enhancers. However, the genes controlled… read more here.
Keywords: interaction maps; range interaction; novel candidate; long range ... See more keywords
Hyperbranched Polyelectrolyte Copolymers as Novel Candidate Delivery Systems for Bio-Relevant Compounds
Sign Up to like & getrecommendations! Published in 2023 at "Materials"
DOI: 10.3390/ma16031045
Abstract: In this study, reversible addition-fragmentation chain transfer (RAFT) polymerization is utilized in order to synthesize novel hyperbranched poly(oligoethylene glycol) methyl ether methacrylate-co-tert-butyl methacrylate-co-methacrylic acid) (H-[P(OEGMA-co-tBMA-co-MAA)]) copolymers in combination with selective hydrolysis reactions. The copolymers showing… read more here.
Keywords: copolymers novel; novel candidate; spectroscopy; candidate delivery ... See more keywords