A novel CCR2 antagonist inhibits atherogenesis in apoE deficient mice by achieving high receptor occupancy
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DOI: 10.1038/s41598-017-00104-z
Abstract: CC Chemokine Receptor 2 (CCR2) and its endogenous ligand CCL2 are involved in a number of diseases, including atherosclerosis. Several CCR2 antagonists have been developed as potential therapeutic agents, however their in vivo clinical efficacy… read more here.
Keywords: high receptor; ccr2; receptor occupancy; novel ccr2 ... See more keywords