Synthesis of d-desthiobiotin-AI-2 as a novel chemical probe for autoinducer-2 quorum sensing receptors.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.103200
Abstract: In processes regulated by quorum sensing (QS) bacteria respond to the concentration of autoinducers in the environment to engage in group behaviours. Autoinducer-2 (AI-2) is unique as it can foster interspecies communication. Currently, two AI-2… read more here.
Keywords: probe; desthiobiotin; quorum sensing; chemical ... See more keywords
Novel chemical probes for the investigation of nonribosomal peptide assembly.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical communications"
DOI: 10.1039/c7cc02427d
Abstract: Chemical probes were devised and evaluated for the capture of biosynthetic intermediates involved in the bio-assembly of the nonribosomal peptide echinomycin. Putative intermediate peptide species were isolated and characterised, providing fresh insights into pathway substrate… read more here.
Keywords: peptide; investigation nonribosomal; nonribosomal peptide; chemical probes ... See more keywords
Historical exposure to chemicals reduces tolerance to novel chemical stress in Daphnia (waterflea)
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Ecology"
DOI: 10.1111/mec.16451
Abstract: Until the last few decades, anthropogenic chemicals used in most production processes have not been comprehensively assessed for their risk and impact on wildlife and humans. They are transported globally and usually end up in… read more here.
Keywords: historical exposure; novel chemical; chemical stress; chemical ... See more keywords
Abstract 689: Identification and optimization of novel chemical matter via a structure-based approach resulting in a probe for MTH1
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-689
Abstract: Cancer cells can form reactive oxygen species (ROS) due to altered redox regulation that affect desoxynucleosides triphosphates (dNTP) in particular. 8-oxo-29-deoxyguanosine-59-triphosphate (8-oxo-dGTP) and 2-hydroxydeoxyadenosine-59-triphosphate (2-OH-dATP) are the two most abundant oxidative nucleotide lesions in this… read more here.
Keywords: chemical matter; structure based; mth1; novel chemical ... See more keywords
A Novel Chemical Binding Primer to Improve Dentin Bonding Durability
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Dental Research"
DOI: 10.1177/00220345221074910
Abstract: The dentin collagen matrix that is not completely enveloped by resin adhesive is vulnerable to degradation by intrinsic collagenases during the etch-and-rinse process, which contributes to the deterioration of the bonding interface. Current commercial adhesives… read more here.
Keywords: dentin collagen; collagen; dentin bonding; chemical binding ... See more keywords
Design of novel chemical solvent for treatment of waxy crude
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Oil, Gas and Coal Technology"
DOI: 10.1504/ijogct.2017.10005466
Abstract: Deposited wax in pipelines and well bores are not easily recoverable due to its solidification over time. This is responsible for losses in production. In this paper, chemical solvent derived from laboratory was used to… read more here.
Keywords: chemical solvent; waxy crude; design novel; solvent ... See more keywords
Novel Chemical Scaffolds to Inhibit the Neutral Amino Acid Transporter B0AT1 (SLC6A19), a Potential Target to Treat Metabolic Diseases
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2020.00140
Abstract: Lack of B0AT1 (SLC6A19) partially protects mice against the onset of non-alcoholic steatohepatitis (NASH). To achieve a similar outcome through pharmacological treatment, we improved previously identified inhibitors of B0AT1 by medicinal chemistry and identified second… read more here.
Keywords: b0at1; amino acid; b0at1 slc6a19; novel chemical ... See more keywords
Novel Chemical and Biological Insights of Inositol Derivatives in Mediterranean Plants
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27051525
Abstract: Inositols (Ins) are natural compounds largely widespread in plants and animals. Bio-sinthetically they derive from sugars, possessing a molecular structure very similar to the simple sugars, and this aspect concurs to define them as primary… read more here.
Keywords: biological insights; chemical biological; inositol derivatives; insights inositol ... See more keywords