Discovery of a novel covalent CDK4/6 inhibitor based on palbociclib scaffold.
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DOI: 10.1016/j.ejmech.2021.113432
Abstract: Cyclin-dependent kinases 4 and 6 (CDK4/6), which are involved in dynamic regulation of cell cycle, play an indispensable role in controlling the tumor growth. Here, based on the scaffold of palbociclib, we designed and synthesized… read more here.
Keywords: palbociclib; discovery novel; covalent cdk4; novel covalent ... See more keywords