A novel CXCR4-targeted near-infrared (NIR) fluorescent probe (Peptide R-NIR750) specifically detects CXCR4 expressing tumors
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-02818-6
Abstract: C-X-C chemokine receptor 4 (CXCR4) is over-expressed in multiple human cancers and correlates with tumor aggressiveness, poor prognosis and increased risk for distant metastases. Imaging agents for CXCR4 are thus highly desirable. We developed a… read more here.
Keywords: probe; nir fluorescent; novel cxcr4; pepr nir750 ... See more keywords
Evaluation of pharmacodynamic (PD) biomarkers in patients with metastatic pancreatic cancer treated with BL-8040, a novel CXCR4 antagonist.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.5_suppl.88
Abstract: 88Background: BL-8040 is a novel CXCR4 antagonist being developed for multiple oncology indications. Preclinical studies demonstrated that BL-8040 increases the number of immune cells in peripheral blood and promotes CD8+ T cell infiltration into orthotropic… read more here.
Keywords: cxcr4 antagonist; metastatic pancreatic; 8040 novel; patients metastatic ... See more keywords
A Novel CXCR4 Antagonist CX549 Induces Neuroprotection in Stroke Brain
Sign Up to like & getrecommendations! Published in 2017 at "Cell Transplantation"
DOI: 10.3727/096368916x693563
Abstract: C-X-C chemokine receptor type 4 (CXCR4) is a receptor for a pleiotropic chemokine CXCL12. Previous studies have shown that the acute administration of the CXCR4 antagonist AMD3100 reduced neuroinflammation in stroke brain and mobilized bone… read more here.
Keywords: cx549; cxcr4 antagonist; stroke brain; novel cxcr4 ... See more keywords