Chemoenzymatic Synthesis of Novel Cytotoxic Epoxyketones Using the Eponemycin Biosynthetic Enzyme EpnF.
Sign Up to like & getrecommendations! Published in 2023 at "ACS chemical biology"
DOI: 10.1021/acschembio.3c00080
Abstract: Eponemycin is an α,β-epoxyketone natural product that inhibits the proteasome via covalent interaction of the epoxyketone warhead with catalytic N-terminal threonine residues. The epoxyketone warhead is biosynthesized from a β-ketoacid substrate by EpnF, a recently… read more here.
Keywords: synthesis novel; epoxyketones using; novel; novel cytotoxic ... See more keywords
A Novel Cytotoxic Steroidal Saponin from the Roots of Asparagus cochinchinensis
Sign Up to like & getrecommendations! Published in 2021 at "Plants"
DOI: 10.3390/plants10102067
Abstract: A new steroidal saponin, 26-O-β-d-glucopyranosyl-(25R)-furost-5-ene-3β,22α,26-triol 3-O-(1−4)-β-d-glucopyranosyl-α-l-rhamnopyranosyl-(1−2)-[α-l-rhamnopyranosyl-(1−4)]-β-d-glucopyranoside [asparacochioside A (1)] was isolated from a hot water extract of the roots of Asparagus cochinchinensis, together with the known steroidal saponins protodioscin (2), methyl protodioscin (3), aspacochioside A… read more here.
Keywords: steroidal saponin; novel cytotoxic; roots asparagus; asparagus cochinchinensis ... See more keywords