Novel dabigatran derivatives with a fluorine atom at the C-2 position of the terminal benzene ring: Design, synthesis and anticoagulant activity evaluation.
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DOI: 10.1016/j.ejmech.2016.12.015
Abstract: This manuscript describes the preparation of dabigatran derivatives and their inhibitory potentials toward human thrombin. Among the tested compounds, 7c, 7k, 7m and 7o, with IC50 values of 1.54, 0.84, 1.18 and 1.42 nM, exhibited comparable… read more here.
Keywords: novel dabigatran; activity; dabigatran; fluorine atom ... See more keywords