Novel derivatives of substituted 6-fluorobenzothiazole diamides: synthesis, antifungal activity and cytotoxicity
Sign Up to like & getrecommendations! Published in 2017 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-017-1894-x
Abstract: A new series of 1-[(1R)-1-(6-fluoro-1,3-benzothiazol-2-yl)ethyl]-3-substituted phenyl diamides were synthesized in vitro as potential antifungal agents. Chemical structures of the synthesised compounds were substantiated by IR, 1H, 13C, 19F nuclear magnetic resonance spectra, high resolution mass… read more here.
Keywords: diamides synthesis; derivatives substituted; fluorobenzothiazole diamides; cytotoxicity ... See more keywords
Convenient on water synthesis of novel derivatives of dicoumarol as functional vitamin K depleter by Fe3O4 magnetic nanoparticles
Sign Up to like & getrecommendations! Published in 2017 at "Arabian Journal of Chemistry"
DOI: 10.1016/j.arabjc.2014.05.030
Abstract: The Fe3O4 nanoparticles were successfully prepared and characterized by X-ray diffraction (XRD), Fourier transform-infrared (FT-IR), and transmission electron microscopy (TEM). The magnetic property of the prepared nanoparticles was investigated by magnetization analysis and the measured… read more here.
Keywords: synthesis novel; convenient water; water synthesis; water ... See more keywords
Synthesis and in vitro biological evaluation of novel derivatives of Flexicaulin A condensation with amino acid trifluoroacetate.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.111645
Abstract: As our research focus on anticancer drugs, two series of novel derivatives of Flexicaulin A (FA), an ent-kaurene diterpene, condensation with amino acid trifluoroacetate were synthesized, and their anti-proliferative activity against four human cancer cell… read more here.
Keywords: condensation amino; amino acid; acid trifluoroacetate; derivatives flexicaulin ... See more keywords
Exploring novel derivatives of isatin-based Schiff bases as multi-target agents: design, synthesis, in vitro biological evaluation, and in silico ADMET analysis with molecular modeling simulations
Sign Up to like & getrecommendations! Published in 2023 at "RSC Advances"
DOI: 10.1039/d3ra00297g
Abstract: Recently, scientists developed a powerful strategy called “one drug-multiple targets” to discover vital and unique therapies to fight the most challenging diseases. Novel derivatives of isatin-based Schiff bases 2–7 have been synthesized by the reaction… read more here.
Keywords: schiff bases; derivatives isatin; based schiff; isatin based ... See more keywords
An Eco-Friendly Stereoselective Synthesis of Novel Derivatives of Indeno[1,2-b]Pyrrole and Indeno[1,2-c]Pyridazine
Sign Up to like & getrecommendations! Published in 2019 at "Polycyclic Aromatic Compounds"
DOI: 10.1080/10406638.2019.1602061
Abstract: Abstract A highly efficient and simple synthesis of a number of pharmaceutically interesting functionalized indenopirrole derivatives has been developed via the reaction of ninhydrin and acetoacetic acid amides in ethanol at the absence of catalyst… read more here.
Keywords: synthesis novel; eco friendly; stereoselective synthesis; friendly stereoselective ... See more keywords
A 3D-QSAR Study on Betulinic Acid Derivatives as Anti-Tumor Agents and the Synthesis of Novel Derivatives for Modeling Validation.
Sign Up to like & getrecommendations! Published in 2017 at "Anti-cancer agents in medicinal chemistry"
DOI: 10.2174/1871520616666160922101712
Abstract: BACKGROUND Betulinic acid is a lupane-type triterpene firstly extracted from the bark of white birch. It has displayed anti-inflammatory, antioxidant, anti-HIV and selective cytotoxicity. OBJECTIVE To understand the structure- anti-tumor activity relationship of betulinic acid… read more here.
Keywords: betulinic acid; anti tumor; acid derivatives; acid ... See more keywords
Synthesis of Novel Derivatives of (Benz)Imidazo[2,1-b]Pyrimido[4,5-d][1,3]Thiazine
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Chemical Research"
DOI: 10.3184/174751917x15132496997778
Abstract: Several derivatives of the novel heterocyclic systems 2-substituted-imidazo- and benzimidazo-[2,1-b]pyrimido[4,5-d][1,3]thiazine have been synthesised through the one-pot cyclocondensation of 2,4-dichloro-5-(chloromethyl)-6-methylpyrimidine with imidazolidine-2-thione and 1H-benzimidazole-2(3H)-thione and subsequently substituted by various secondary amines in moderately good yields. read more here.
Keywords: synthesis novel; pyrimido; derivatives benz; pyrimido thiazine ... See more keywords
Novel Derivatives of Eugenol as a New Class of PPARγ Agonists in Treating Inflammation: Design, Synthesis, SAR Analysis and In Vitro Anti-Inflammatory Activity
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28093899
Abstract: The main objective of this research was to develop novel compounds from readily accessed natural products especially eugenol with potential biological activity. Eugenol, the principal chemical constituent of clove (Eugenia caryophyllata) from the family Myrtaceae… read more here.
Keywords: ppar; anti inflammatory; inflammatory activity; activity ... See more keywords
Synthesis of novel derivatives of chromenone bearing an $N$-carbamothioyl moiety as soybean 15-LOX inhibitors
Sign Up to like & getrecommendations! Published in 2017 at "Turkish Journal of Chemistry"
DOI: 10.3906/kim-1604-13
Abstract: Novel derivatives of chromenone bearing an $N$-carbamothioyl moiety were synthesized and evaluated for their soybean 15-LOX inhibitory activity. Synthesis of the target compounds was started from 7-hydroxy-2$H$-chromen-2-one. It was reacted with 1-fluoro-2(4)-nitrobenzene to obtain the… read more here.
Keywords: soybean lox; bearing carbamothioyl; derivatives chromenone; carbamothioyl ... See more keywords