A Combined Chemical, Computational, and In Vitro Approach Identifies SBL-105 as Novel DHODH Inhibitor in Acute Myeloid Leukemia Cells
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DOI: 10.3727/096504021x16281573507558
Abstract: Inhibition of the dihydroorotate dehydrogenase (DHODH) has been successful at the preclinical level in controlling myeloid leukemia. However, poor clinical trials warrant the search for new potent DHODH inhibitors. Herein we present a novel DHODH… read more here.
Keywords: myeloid leukemia; novel dhodh; cell; sbl 105 ... See more keywords