Opportunities for novel diagnostic and cell-based therapies for Hirschsprung disease.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of pediatric surgery"
DOI: 10.1016/j.jpedsurg.2021.10.049
Abstract: Despite significant progress in our understanding of the etiology and pathophysiology of Hirschsprung disease (HSCR), early and accurate diagnosis and operative management can be challenging. Moreover, long-term morbidity following surgery, including fecal incontinence, constipation, and… read more here.
Keywords: diagnostic cell; cell based; opportunities novel; disease ... See more keywords
NFATc2-rearranged sarcomas: clinicopathologic, molecular, and cytogenetic study of 7 cases with evidence of AGGRECAN as a novel diagnostic marker
Sign Up to like & getrecommendations! Published in 2020 at "Modern Pathology"
DOI: 10.1038/s41379-020-0542-z
Abstract: NFATc2-rearranged sarcomas (NFATc2-Sarcomas) are infrequent round cell tumors characterized by EWSR1-NFATc2 fusions and FUS-NFATc2 fusions. Although our knowledge on these neoplasms has increased recently, novel diagnostic tools and more comprehensive series are still needed. Here,… read more here.
Keywords: ewsr1 nfatc2; novel diagnostic; nfatc2 rearranged; study ... See more keywords
Circular RNAs: novel diagnostic and therapeutic targets for ischemic stroke
Sign Up to like & getrecommendations! Published in 2020 at "Expert Review of Molecular Diagnostics"
DOI: 10.1080/14737159.2020.1826313
Abstract: ABSTRACT Introduction Ischemic stroke is a life-threatening condition worldwide, including China. Nowadays, intravenous thrombolysis and mechanical thrombectomy are chiefly applied as clinical therapeutics; however, strict time windows and underlying risks limit their benefits for patients.… read more here.
Keywords: ischemic stroke; circular rnas; novel diagnostic; therapeutic targets ... See more keywords
microRNAs as Novel Diagnostic Biomarkers in Endometriosis Patients: A systematic review and meta-analysis.
Sign Up to like & getrecommendations! Published in 2021 at "Expert review of molecular diagnostics"
DOI: 10.1080/14737159.2021.1960508
Abstract: OBJECTIVE To investigate whether miRNAs have a remarkable pooled diagnostic accuracy, sensitivity and specificity as non-invasive biomarkers to distinguish endometriosis patients from non-endometriosis women. METHODS A comprehensive literature search of PubMed, Embase and ProQuest was… read more here.
Keywords: micrornas novel; analysis; novel diagnostic; review ... See more keywords
Is a novel diagnostic pathway for cardiology outpatient clinics in Singapore lower cost than existing practice: a cost modelling study
Sign Up to like & getrecommendations! Published in 2022 at "BMJ Open"
DOI: 10.1136/bmjopen-2021-050553
Abstract: Objective To evaluate the potential for change to costs from a decision to adopt a novel diagnostic pathway for referrals to cardiology outpatients with symptoms of chest pain. Design Costs modelling study using existing observational… read more here.
Keywords: novel diagnostic; diagnostic pathway; practice; modelling study ... See more keywords
Identification of novel diagnostic biomarkers for thyroid carcinoma
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DOI: 10.18632/oncotarget.22873
Abstract: Thyroid carcinoma (THCA) is the most universal endocrine malignancy worldwide. Unfortunately, a limited number of large-scale analyses have been performed to identify biomarkers for THCA. Here, we conducted a meta-analysis using 505 THCA patients and… read more here.
Keywords: diagnostic biomarkers; novel diagnostic; biomarkers thca; biomarkers thyroid ... See more keywords
Ferroptosis Is a Potential Novel Diagnostic and Therapeutic Target for Patients With Cardiomyopathy
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.649045
Abstract: Cardiomyocyte death is a fundamental progress in cardiomyopathy. However, the mechanism of triggering the death of myocardial cells remains unclear. Ferroptosis, which is the nonapoptotic, iron-dependent, and peroxidation-driven programmed cell death pathway, that is abundant… read more here.
Keywords: potential novel; novel diagnostic; diagnostic therapeutic; ferroptosis ... See more keywords
APOC1 as a novel diagnostic biomarker for DN based on machine learning algorithms and experiment
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2023.1102634
Abstract: Introduction Diabetic nephropathy is the leading cause of end-stage renal disease, which imposes a huge economic burden on individuals and society, but effective and reliable diagnostic markers are still not available. Methods Differentially expressed genes… read more here.
Keywords: novel diagnostic; apoc1 novel; expression; diagnostic biomarker ... See more keywords
A novel diagnostic four-gene signature for hepatocellular carcinoma based on artificial neural network: Development, validation, and drug screening
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.942166
Abstract: Background: Hepatocellular carcinoma (HCC) is one of the most common cancers with high mortality in the world. HCC screening and diagnostic models are becoming effective strategies to reduce mortality and improve the overall survival (OS)… read more here.
Keywords: novel diagnostic; hepatocellular carcinoma; diagnostic model; hcc ... See more keywords
Novel diagnostic techniques in interstitial lung disease
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2023.1174443
Abstract: Research into novel diagnostic techniques and targeted therapeutics in interstitial lung disease (ILD) is moving the field toward increased precision and improved patient outcomes. An array of molecular techniques, machine learning approaches and other innovative… read more here.
Keywords: novel diagnostic; lung disease; diagnostic techniques; interstitial lung ... See more keywords
Apolipoprotein C1 (APOC1): A Novel Diagnostic and Prognostic Biomarker for Clear Cell Renal Cell Carcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2020.01436
Abstract: Background: Apolipoprotein C1 (APOC1) has been proved to play a critical role in gastric, breast, lung, and pancreatic cancer. However, the relationship between APOC1 and urinary tumors remains unclear. This study aimed to assess the… read more here.
Keywords: diagnostic prognostic; novel diagnostic; apolipoprotein apoc1; expression ... See more keywords