Novel diaryl-2H-azirines: Antitumor hybrids for dual-targeting tubulin and DNA.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113256
Abstract: Multiple-target drugs may achieve better therapeutic effect via different pathways than single-target ones, especially for complex diseases. Tubulin and DNA are well-characterized molecular targets for anti-cancer drug development. A novel class of diaryl substituted 2H-azirines… read more here.
Keywords: novel diaryl; targeting tubulin; tubulin dna; dna ... See more keywords
A11, a novel diaryl acylhydrazone derivative, exerts neuroprotection against ischemic injury in vitro and in vivo
Sign Up to like & getrecommendations! Published in 2018 at "Acta Pharmacologica Sinica"
DOI: 10.1038/s41401-018-0028-4
Abstract: There is an urgent need to develop effective therapies for ischemic stroke, but the complicated pathological processes after ischemia make doing so difficult. In the current study, we identified a novel diaryl acylhydrazone derivative, A11,… read more here.
Keywords: novel diaryl; ischemic stroke; diaryl; diaryl acylhydrazone ... See more keywords