Identification and Profiling of a Novel Diazaspiro[3.4]octane Chemical Series Active against Multiple Stages of the Human Malaria Parasite Plasmodium falciparum and Optimization Efforts.
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DOI: 10.1021/acs.jmedchem.1c00034
Abstract: A novel diazaspiro[3.4]octane series was identified from a Plasmodium falciparum whole-cell high-throughput screening campaign. Hits displayed activity against multiple stages of the parasite lifecycle, which together with a novel sp3-rich scaffold provided an attractive starting… read more here.
Keywords: diazaspiro octane; chemistry; plasmodium falciparum; multiple stages ... See more keywords