Identification of novel DNA sequence associated with pathogenicity island III536 locus in Uropathogenic Escherichia coli isolate and distribution of virulence determinants in β-lactam resistant isolates
Sign Up to like & getrecommendations! Published in 2018 at "Microbial Pathogenesis"
DOI: 10.1016/j.micpath.2018.07.035
Abstract: Abstract Background There is an increase in the number of Enterobacteriaceae with Extended-spectrum beta-lactamase (ESBL) type of antibiotic resistance in the Kingdom of Bahrain. However, the virulence determinants of the clinical isolates have not been… read more here.
Keywords: escherichia coli; virulence; virulence determinants; novel dna ... See more keywords
Novel DNA Aptamer for CYP24A1 Inhibition with Enhanced Antiproliferative Activity in Cancer Cells.
Sign Up to like & getrecommendations! Published in 2022 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.1c22965
Abstract: Overexpression of the vitamin D3-inactivating enzyme CYP24A1 (cytochrome P450 family 24 subfamily and hereafter referred to as CYP24) can cause chronic kidney diseases, osteoporosis, and several types of cancers. Therefore, CYP24 inhibition has been considered… read more here.
Keywords: inhibition; cyp24; activity; novel dna ... See more keywords
Novel DNA Biosensor for Direct Determination of Carrageenan
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-42757-y
Abstract: A novel disposable electrochemical biosensor based on immobilized calf thymus double-stranded DNA (dsDNA) on the carbon-based screen-printed electrode (SPE) is developed for rapid biorecognition of carrageenan by using methylene blue (MB) redox indicator. The biosensor… read more here.
Keywords: dna biosensor; biosensor; biosensor direct; carrageenan ... See more keywords
Abstract 2967: Preclinical development of a B7-H3-targeting ADC with a novel DNA topoisomerase I inhibitor for solid tumors
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-2967
Abstract: Introduction: B7-H3 (CD276) is an immunomodulatory protein of the B7 superfamily molecules, it is overexpressed in a wide range of solid tumors. B7-H3 overexpression often correlates with poor survival and higher tumor grade, it has… read more here.
Keywords: development; dna topoisomerase; solid tumors; novel dna ... See more keywords
Abstract 5797: NTX301, a novel DNA hypomethylating agent, targets lipid metabolism in ovarian cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-5797
Abstract: Background: DNA methylation causes the silencing of tumor suppressor and differentiation-associated genes being linked to chemoresistance and stemness. Previous studies demonstrated that hypomethylating agents (HMA) re-sensitize ovarian cancer (OC) cells to chemotherapy, however, translation to… read more here.
Keywords: ovarian cancer; ntx301 novel; ntx301; novel dna ... See more keywords
A Novel DNA Vaccine Against SARS-CoV-2 Encoding a Chimeric Protein of Its Receptor-Binding Domain (RBD) Fused to the Amino-Terminal Region of Hepatitis B Virus preS1 With a W4P Mutation
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.637654
Abstract: A coronavirus SARS-CoV-2, which has caused the pandemic viral pneumonia disease COVID-19, significantly threatens global public health, highlighting the need to develop effective and safe vaccines against its infection. In this study, we developed a… read more here.
Keywords: protein; novel dna; rbd; w4p ... See more keywords
A novel DNA methylation marker to identify lymph node metastasis of colorectal cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.1000823
Abstract: Lymph node metastasis (LNM) of colorectal cancer (CRC) is an important factor for both prognosis and treatment. Given the deficiencies of conventional tests, we aim to discover novel DNA methylation markers to efficiently identify LNM… read more here.
Keywords: methylation; marker; node metastasis; colorectal cancer ... See more keywords