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   Articles with "novel drug" as a keyword



A Novel Drug Candidate for Sepsis Targeting Heparanase by Inhibiting Cytokine Storm (Adv. Sci. 29/2024)

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recommendations! Published in 2024 at "Advanced Science"

DOI: 10.1002/advs.202470175

Abstract: Novel Drug Candidate for Sepsis Sepsis currently has no specific clinical treatment. The main cause of multi‐organ failure and death in sepsis is increased vascular permeability due to endothelial damage. Hongzhen Jin, Wei Zhao, Fan… read more here.

Keywords: novel drug; drug; candidate sepsis; drug candidate ... See more keywords

A Transcriptomic Approach to Identify Novel Drug Efflux Pumps in Bacteria.

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recommendations! Published in 2018 at "Methods in molecular biology"

DOI: 10.1007/978-1-4939-7454-2_12

Abstract: The core genomes of most bacterial species include a large number of genes encoding putative efflux pumps. The functional roles of most of these pumps are unknown, however, they are often under tight regulatory control… read more here.

Keywords: novel drug; identify novel; drug efflux; efflux pumps ... See more keywords

Tocosome: Novel drug delivery system containing phospholipids and tocopheryl phosphates.

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recommendations! Published in 2017 at "International journal of pharmaceutics"

DOI: 10.1016/j.ijpharm.2017.06.037

Abstract: The potential of two derivatives of vitamin E, i.e. α-tocopheryl phosphate (TP) and di-α-tocopheryl phosphate (T2P), for the protection and delivery of therapeutics is being investigated in our laboratory and some promising results have been… read more here.

Keywords: novel drug; tocopheryl; drug delivery; delivery ... See more keywords

Discovery of Novel Drug-Conjugate Molecule ZM484 with Dual p53-MDM2 and TOP1 Inhibition for the Treatment of Colorectal Cancer.

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recommendations! Published in 2025 at "Journal of medicinal chemistry"

DOI: 10.1021/acs.jmedchem.5c01003

Abstract: The blocking interaction between p53 and its negative regulator MDM2 is an engaging therapeutic strategy for antitumor drug development, and there are several drug candidates of p53-MDM2 inhibitors in clinical trials. In the present study,… read more here.

Keywords: novel drug; treatment; p53 mdm2; drug ... See more keywords

Temporal trends in evidence supporting novel drug target discovery.

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recommendations! Published in 2025 at "Nature communications"

DOI: 10.1038/s41467-025-67180-y

Abstract: Over the past decade, about one-fifth of FDA-approved drugs each year involve novel mechanism-of-action human targets. Although riskier than modulating well-known targets, these therapies address unmet needs and strengthen sector innovation. The Open Targets Platform… read more here.

Keywords: novel drug; evidence supporting; target; evidence ... See more keywords

Advances in novel drug delivery systems: a focus on nanoparticles and mucoadhesive technologies

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recommendations! Published in 2025 at "Drug Development and Industrial Pharmacy"

DOI: 10.1080/03639045.2025.2564364

Abstract: Abstract Objective To explore the advancements and therapeutic potential of nanocarrier-based drug delivery systems in improving drug administration, targeting efficiency, and patient outcomes, particularly in complex disease management. Significance Traditional drug delivery methods often suffer… read more here.

Keywords: novel drug; drug delivery; delivery; delivery systems ... See more keywords

Uterine fibroids: current research on novel drug targets and innovative therapeutic strategies

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recommendations! Published in 2024 at "Expert Opinion on Therapeutic Targets"

DOI: 10.1080/14728222.2024.2390094

Abstract: ABSTRACT Introduction Uterine fibroids, the most common nonmalignant tumors affecting the female genital tract, are a significant medical challenge. This article focuses on the most recent studies that attempted to identify novel non-hormonal therapeutic targets… read more here.

Keywords: novel drug; current research; fibroids current; drug ... See more keywords

Advances with support vector machines for novel drug discovery

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recommendations! Published in 2019 at "Expert Opinion on Drug Discovery"

DOI: 10.1080/17460441.2019.1549033

Abstract: ABSTRACT Introduction: Novel drug discovery remains an enormous challenge, with various computer-aided drug design (CADD) approaches having been widely employed for this purpose. CADD, specifically the commonly used support vector machines (SVMs), can employ machine… read more here.

Keywords: novel drug; support vector; drug; vector machines ... See more keywords

Ixazomib: a novel drug for multiple myeloma

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recommendations! Published in 2018 at "Expert Review of Hematology"

DOI: 10.1080/17474086.2018.1518129

Abstract: ABSTRACT Introduction: Proteasome inhibitors (PIs) have been an integral part of treatment for multiple myeloma (MM) over the past decade. Many newer PIs are being evaluated in pre-clinical and clinical setting, with an aim to… read more here.

Keywords: novel drug; efficacy; drug; multiple myeloma ... See more keywords

Emicizumab: a novel drug in hemophilia A prophylaxis – a narrative review

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recommendations! Published in 2022 at "Expert Review of Hematology"

DOI: 10.1080/17474086.2022.2131526

Abstract: ABSTRACT Introduction Hemophilia A is a genetically conditioned disease leading to hemostatic disorders due to factor VIII (FVIII) deficiency. The treatment of hemophilia has evolved throughout the past years and has significantly changed. One of… read more here.

Keywords: hemophilia prophylaxis; review; factor; emicizumab novel ... See more keywords

Galleria mellonella as a consolidated in vivo model hosts: New developments in antibacterial strategies and novel drug testing

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recommendations! Published in 2019 at "Virulence"

DOI: 10.1080/21505594.2019.1621649

Abstract: ABSTRACT A greater ethical conscience, new global rules and a modified perception of ethical consciousness entail a more rigorous control on utilizations of vertebrates for in vivo studies. To cope with this new scenario, numerous… read more here.

Keywords: novel drug; antibacterial strategies; strategies novel; mellonella ... See more keywords