A Transcriptomic Approach to Identify Novel Drug Efflux Pumps in Bacteria.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7454-2_12
Abstract: The core genomes of most bacterial species include a large number of genes encoding putative efflux pumps. The functional roles of most of these pumps are unknown, however, they are often under tight regulatory control… read more here.
Keywords: novel drug; identify novel; drug efflux; efflux pumps ... See more keywords
Tocosome: Novel drug delivery system containing phospholipids and tocopheryl phosphates.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2017.06.037
Abstract: The potential of two derivatives of vitamin E, i.e. α-tocopheryl phosphate (TP) and di-α-tocopheryl phosphate (T2P), for the protection and delivery of therapeutics is being investigated in our laboratory and some promising results have been… read more here.
Keywords: novel drug; tocopheryl; drug delivery; delivery ... See more keywords
Advances with support vector machines for novel drug discovery
Sign Up to like & getrecommendations! Published in 2019 at "Expert Opinion on Drug Discovery"
DOI: 10.1080/17460441.2019.1549033
Abstract: ABSTRACT Introduction: Novel drug discovery remains an enormous challenge, with various computer-aided drug design (CADD) approaches having been widely employed for this purpose. CADD, specifically the commonly used support vector machines (SVMs), can employ machine… read more here.
Keywords: novel drug; support vector; drug; vector machines ... See more keywords
Ixazomib: a novel drug for multiple myeloma
Sign Up to like & getrecommendations! Published in 2018 at "Expert Review of Hematology"
DOI: 10.1080/17474086.2018.1518129
Abstract: ABSTRACT Introduction: Proteasome inhibitors (PIs) have been an integral part of treatment for multiple myeloma (MM) over the past decade. Many newer PIs are being evaluated in pre-clinical and clinical setting, with an aim to… read more here.
Keywords: novel drug; efficacy; drug; multiple myeloma ... See more keywords
Emicizumab: a novel drug in hemophilia A prophylaxis – a narrative review
Sign Up to like & getrecommendations! Published in 2022 at "Expert Review of Hematology"
DOI: 10.1080/17474086.2022.2131526
Abstract: ABSTRACT Introduction Hemophilia A is a genetically conditioned disease leading to hemostatic disorders due to factor VIII (FVIII) deficiency. The treatment of hemophilia has evolved throughout the past years and has significantly changed. One of… read more here.
Keywords: hemophilia prophylaxis; review; factor; emicizumab novel ... See more keywords
Galleria mellonella as a consolidated in vivo model hosts: New developments in antibacterial strategies and novel drug testing
Sign Up to like & getrecommendations! Published in 2019 at "Virulence"
DOI: 10.1080/21505594.2019.1621649
Abstract: ABSTRACT A greater ethical conscience, new global rules and a modified perception of ethical consciousness entail a more rigorous control on utilizations of vertebrates for in vivo studies. To cope with this new scenario, numerous… read more here.
Keywords: novel drug; antibacterial strategies; strategies novel; mellonella ... See more keywords
A Systematic In Silico Analysis of the Legionellaceae Family for Identification of Novel Drug Target Candidates.
Sign Up to like & getrecommendations! Published in 2019 at "Microbial drug resistance"
DOI: 10.1089/mdr.2017.0328
Abstract: The family Legionellaceae consists of Gram-negative bacteria that are widely distributed in aquatic environments around the world. This family consists of a single genus, Legionella, that is recognized as an important cause of community-acquired pneumonia… read more here.
Keywords: novel drug; family; drug; identification novel ... See more keywords
A novel drug repurposing approach for non-small cell lung cancer using deep learning
Sign Up to like & getrecommendations! Published in 2020 at "PLoS ONE"
DOI: 10.1371/journal.pone.0233112
Abstract: Drug repurposing is an attractive and pragmatic way offering reduced risks and development time in the complicated process of drug discovery. In the past, drug repurposing has been largely accidental and serendipitous. The most successful… read more here.
Keywords: novel drug; drug repurposing; drug; cell ... See more keywords
A Candidemia Case Caused by a Novel Drug-Resistant Candida auris with the Y132F Mutation in Erg11 in Mainland China
Sign Up to like & getrecommendations! Published in 2023 at "Infection and Drug Resistance"
DOI: 10.2147/idr.s409708
Abstract: Background Candida auris is a pathogen first found in external ear canal, becoming a major threat to global health. Here, we describe a candidemia case caused by a novel drug-resistant Candida auris strain. Case Presentation… read more here.
Keywords: candida auris; auris; novel drug; y132f mutation ... See more keywords
Novel Drug Delivery Systems for Loading of Natural Plant Extracts and Their Biomedical Applications
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Nanomedicine"
DOI: 10.2147/ijn.s227805
Abstract: Abstract Many types of research have distinctly addressed the efficacy of natural plant metabolites used for human consumption both in cell culture and preclinical animal model systems. However, these in vitro and in vivo effects… read more here.
Keywords: drug delivery; novel drug; delivery; delivery systems ... See more keywords
Introduction of novel drug targets against Staphylococcus aureus and proposing putative inhibitors against adenine N1 (m1A22)-tRNA methyltransferase (TrmK) using computer-aided drug discovery.
Sign Up to like & getrecommendations! Published in 2023 at "Current pharmaceutical design"
DOI: 10.2174/1381612829666230428105643
Abstract: BACKGROUND Nowadays, the emergence of methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant S. aureus (VRSA) strains has dramatically restricted the treatment options against this microorganism. Therefore, in this study, we aimed to discover new drug targets… read more here.
Keywords: staphylococcus aureus; hit compounds; novel drug; drug ... See more keywords