Use of US Food and Drug Administration Expedited Drug Development and Review Programs by Orphan and Nonorphan Novel Drugs Approved From 2008 to 2021
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.39336
Abstract: This cross-sectional study examines how often and in what combinations 4 US Food and Drug Administration programs for expedited development and review of novel drugs were used among orphan and nonorphan biologics and small-molecule drugs… read more here.
Keywords: novel drugs; food drug; orphan nonorphan; drug administration ... See more keywords
Chemical Chaperones as Novel Drugs for Parkinson's Disease.
Sign Up to like & getrecommendations! Published in 2020 at "Trends in molecular medicine"
DOI: 10.1016/j.molmed.2020.01.005
Abstract: Parkinson's disease (PD) is characterized by progressive loss of dopaminergic neurons and the accumulation of deposits of α-synuclein (α-syn) in the brain. The pivotal role of α-syn aggregation in PD makes it an attractive target… read more here.
Keywords: disease; chaperones novel; novel drugs; drugs parkinson ... See more keywords
Identifying novel drugs with new modes of action for neglected tropical fungal skin diseases (fungal skinNTDs) using an Open Source Drug discovery approach
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Drug Discovery"
DOI: 10.1080/17460441.2022.2080195
Abstract: ABSTRACT Introduction The three fungal skin neglected tropical diseases (NTD) – mycetoma, chromoblastomycosis and sporotrichosis – currently lack prioritization and support to establish drug discovery programs in search for novel treatment options. This has made… read more here.
Keywords: fungal skinntds; drug discovery; skinntds; novel drugs ... See more keywords
Application of Novel Drugs for Corneal Cell Regeneration
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Ophthalmology"
DOI: 10.1155/2018/1215868
Abstract: Corneal transplantation has been the only treatment method for corneal blindness, which is the major cause of reversible blindness. However, despite the advancement of surgical techniques for corneal transplantation, demand for the surgery can never… read more here.
Keywords: novel drugs; corneal cell; application novel; cell regeneration ... See more keywords
Topological Indices of Novel Drugs Used in Autoimmune Disease Vitiligo Treatment and Its QSPR Modeling
Sign Up to like & getrecommendations! Published in 2022 at "BioMed Research International"
DOI: 10.1155/2022/6045066
Abstract: A topological index is a real number derived from the structure of a chemical graph. It is helpful to determine the physicochemical and biological properties of a wide range of drugs, and it better reflects… read more here.
Keywords: qspr; indices novel; novel drugs; drugs used ... See more keywords
Novel Drugs for Diabetes Also Have Dramatic Benefits on Hard Outcomes of Heart and Kidney Disease.
Sign Up to like & getrecommendations! Published in 2022 at "Current cardiology reviews"
DOI: 10.2174/1573403x18666220511114443
Abstract: • Background: Diabetes is a major risk factor for developing cardiovascular disease. Patients with both diabetes and cardiovascular disease have even higher mortality. The convergence of cardiology and diabetology therapy is an important step in… read more here.
Keywords: novel drugs; cardiovascular disease; disease; cardiology ... See more keywords
Novel Drugs and Radiotherapy in Relapsed Lymphomas: Abscopal Response and Beyond
Sign Up to like & getrecommendations! Published in 2023 at "Cancers"
DOI: 10.3390/cancers15102751
Abstract: Simple Summary Relapsed or refractory (r/r) lymphomas represent hard-to-treat cancers with dismal prognoses. Over the past few years, immune checkpoint inhibitors targeting programmed cell death protein 1 (PD-1) and programmed cell death ligand 1 (PD-L1)… read more here.
Keywords: novel drugs; drugs radiotherapy; radiotherapy; relapsed lymphomas ... See more keywords
[The impact of novel drugs on the survival of patients with multiple myeloma in two chilean centers].
Sign Up to like & getrecommendations! Published in 2022 at "Revista medica de Chile"
DOI: 10.4067/s0034-98872022000300331
Abstract: BACKGROUND The incorporation of novel drugs, such as proteasome inhibitors and immunomodulators, improved considerably the survival of patients with multiple myeloma. AIM To evaluate the effect on survival of proteasome inhibitors and immunomodulators in patients… read more here.
Keywords: myeloma two; novel drugs; impact novel; patients multiple ... See more keywords