Novel endosomolytic compounds enable highly potent delivery of antisense oligonucleotides
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DOI: 10.1038/s42003-022-03132-2
Abstract: The therapeutic and research potentials of oligonucleotides (ONs) have been hampered in part by their inability to effectively escape endosomal compartments to reach their cytosolic and nuclear targets. Splice-switching ONs (SSOs) can be used with… read more here.
Keywords: sso trafficking; delivery; novel endosomolytic; endosomolytic compounds ... See more keywords