YEATS Domains as Novel Epigenetic Readers: Structures, Functions, and Inhibitor Development.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical biology"
DOI: 10.1021/acschembio.1c00945
Abstract: Interpretation of the histone posttranslational modifications (PTMs) by effector proteins, or readers, is an important epigenetic mechanism to regulate gene function. YEATS domains have been recently identified as novel readers of histone lysine acetylation and… read more here.
Keywords: development yeats; yeats domains; development; epigenetic readers ... See more keywords
TET2: A Novel Epigenetic Regulator and Potential Intervention Target for Atherosclerosis.
Sign Up to like & getrecommendations! Published in 2018 at "DNA and cell biology"
DOI: 10.1089/dna.2017.4118
Abstract: Atherosclerosis is the underlying cause of cardio-cerebrovascular disease. However, the mechanisms of atherosclerosis are still unclear. The modification of DNA methylation has an important role in atherosclerosis development. As a member of the Ten-eleven translocation… read more here.
Keywords: tet2 novel; tet2; target atherosclerosis; novel epigenetic ... See more keywords
BET inhibitors: a novel epigenetic approach
Sign Up to like & getrecommendations! Published in 2017 at "Annals of Oncology"
DOI: 10.1093/annonc/mdx157
Abstract: Epigenetics has been defined as 'the structural adaptation of chromosomal regions so as to register, signal or perpetuate altered activity states.' Currently, several classes of anticancer drugs function at the epigenetic level, including inhibitors of… read more here.
Keywords: bet proteins; inhibitors novel; approach; epigenetic approach ... See more keywords
Promoter methylation changes in ALOX12 and AIRE1: novel epigenetic markers for atherosclerosis
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Epigenetics"
DOI: 10.1186/s13148-020-00846-0
Abstract: Atherosclerosis is the main cause of cardiovascular diseases such as ischemic stroke and coronary heart disease. Gene-specific promoter methylation changes have been suggested as one of the causes underlying the development of atherosclerosis. We aimed… read more here.
Keywords: methylation; alox12 aire1; promoter methylation; methylation changes ... See more keywords
ARHI is a novel epigenetic silenced tumor suppressor in sporadic pheochromocytoma
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.21149
Abstract: Pheochromocytoma (PCC) is related to germline mutations in 12 susceptibility genes. Although comparative genomic hybridization array has revealed some putative tumor suppressor genes on the short arm of chromosome 1 that are likely to be… read more here.
Keywords: arhi; arhi novel; tumor suppressor; novel epigenetic ... See more keywords
Novel epigenetic link between gestational diabetes mellitus and macrosomia.
Sign Up to like & getrecommendations! Published in 2021 at "Epigenomics"
DOI: 10.2217/epi-2021-0096
Abstract: Background & objectives: Examine maternal gestational diabetes mellitus (GDM), macrosomia and DNA methylation in candidate genes IGF1, IGF2, H19, ARHGRF11, MEST, NR3C1, ADIPOQ and RETN. Materials & methods: 1145 Children (572 GDM cases and 573 controls) from The Tianjin… read more here.
Keywords: gestational diabetes; epigenetic link; diabetes mellitus; link gestational ... See more keywords