Novel FFA1 (GPR40) agonists containing spirocyclic periphery: polar azine periphery as a driver of potency
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DOI: 10.1080/14756366.2016.1230110
Abstract: Abstract A series of nine compounds based on 3-[4-(benzyloxy)phenyl]propanoic acid core containing a 1-oxa-9-azaspiro[5.5]undecane periphery was designed, synthesized and evaluated as free fatty acid 1 (FFA1 or GPR40) agonists. The spirocyclic appendages included in these… read more here.
Keywords: ffa1; novel ffa1; ffa1 gpr40; gpr40 agonists ... See more keywords