Synthesis and structure-activity relationship of tyrosinase inhibiting novel bi-heterocyclic acetamides: Mechanistic insights through enzyme inhibition, kinetics and computational studies.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.01.036
Abstract: The present research was designed for the selective synthesis of novel bi-heterocyclic acetamides, 9a-n, and their tyrosinase inhibition to overwhelm the problem of melanogenesis. The structures of newly synthesized compounds were confirmed by spectral techniques… read more here.
Keywords: heterocyclic acetamides; inhibition; novel heterocyclic; tyrosinase ... See more keywords
Novel heterocyclic disazo dyes containing pyrazole and phenylpyrazole. part 1: Synthesis, characterization, solvent polarity and acid-base sensitive characteristics
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2021.129960
Abstract: Abstract A series of diazotised aniline and aniline derivative compounds were reacted with solution of malononitrile in pyridine at 0–5 °C were obtained 1a-1m compounds. Then 4-arylazo-3,5-diamino-1H-pyrazole (2a-2m) derivatives were synthesized by coupling arylazo malononitrile… read more here.
Keywords: novel heterocyclic; dyes containing; spectroscopy; containing pyrazole ... See more keywords
Unexpected synthesis of a novel heterocyclic system - (7E,10aE)-2,7-Dimethylfuro[3',4':6,7]cycloocta[1,2,3-cd]indole-8,10(2H,6H)-dione
Sign Up to like & getrecommendations! Published in 2017 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2017.05.062
Abstract: Abstract The first derivative of a novel heterocyclic system, (7 E ,10a E )-2,7-dimethylfuro[3′,4′:6,7]-cycloocta[1,2,3- cd ]indole-8,10(2 H ,6 H )-dione, was synthesized based on the Stobbe condensation of 3-chloro-1-methylindole-2-carbaldehyde with diethyl isopropylidenesuccinate. Cyclization of the… read more here.
Keywords: cycloocta indole; heterocyclic system; novel heterocyclic; indole dione ... See more keywords
Novel N-heterocyclic Stannylenes (NHSns) Using DFT
Sign Up to like & getrecommendations! Published in 2019 at "Physical Chemistry Research"
DOI: 10.22036/pcr.2019.172684.1597
Abstract: Substitution effects are probed for novel N-heterocyclic stannylenes (NHSns), including 1,4-di(R)-tetrazole-5-stannylenes (1R), and 1,3-di(R)-tetrazole-5-stannylenes (2R), using B3LYP/6-311++G** level of theory. Nucleophilicity, multiplicity, and stability of 1R and 2R are calculated; with R = H, methyl,… read more here.
Keywords: novel heterocyclic; using dft; stannylenes nhsns; propyl ... See more keywords
The Effect of Novel Heterocyclic Compounds on Cryptococcal Biofilm
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Fungi"
DOI: 10.3390/jof3030042
Abstract: Biofilm formation by microorganisms depends on their communication by quorum sensing, which is mediated by small diffusible signaling molecules that accumulate in the extracellular environment. During human infection, the pathogenic yeast Cryptococcus neoformans can form… read more here.
Keywords: heterocyclic compounds; effect novel; novel heterocyclic; biofilm ... See more keywords
Synthesis and Characterization of Novel Heterocyclic Chalcones from 1-Phenyl-1H-pyrazol-3-ol
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27123752
Abstract: An efficient synthetic route to construct diverse pyrazole-based chalcones from 1-phenyl-1H-pyrazol-3-ols bearing a formyl or acetyl group on the C4 position of pyrazole ring, employing a base-catalysed Claisen–Schmidt condensation reaction, is described. Isomeric chalcones were… read more here.
Keywords: characterization novel; heterocyclic chalcones; novel heterocyclic; chalcones phenyl ... See more keywords