First-in-Man Safety, Tolerability, and Pharmacokinetics of a Novel and Highly Selective Inhibitor of Matrix Metalloproteinase-12, FP-025: Results from Two Randomized Studies in Healthy Subjects
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Drug Investigation"
DOI: 10.1007/s40261-020-00981-9
Abstract: Background and Objectives Matrix metalloproteinases (MMPs) are proteases with different biological and pathological activities, and many have been linked to several diseases. Targeting individual MMPs may offer a safer therapeutic potential for several diseases. We… read more here.
Keywords: highly selective; safety tolerability; capsule; study ... See more keywords
Highly improving the mechanical-responses/thermal-stability of the epoxy nano-composite using novel highly-oxidized multi-walled carbon nanotubes (OMWCNT) functionalized by Zinc-doped Polyaniline (PANI) nanofibers
Sign Up to like & getrecommendations! Published in 2021 at "Journal of The Taiwan Institute of Chemical Engineers"
DOI: 10.1016/j.jtice.2021.02.008
Abstract: Abstract Herein, the synthesis of a novel highly-oxidized carbon nanotubes (OMWCNT) modified by the Emeraldine salt (ES)-based polyaniline (PANI) nanofibers (NFs) was carried out. The zinc doped OMWCNT-PANI particles were synthesized to achieve novel nanoparticles,… read more here.
Keywords: pani; pani nanofibers; carbon nanotubes; nano composite ... See more keywords
Novel highly selective and sensitive fluorescent sensor for copper detection based on N-acylhydrazone acridone derivative
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2019.126990
Abstract: Abstract A new N-acylhydrazone based on acridone (S1) was synthesized by Schiff base condensation of 2-(9-oxoacridin-10-yl)acetohydrazide and salicylaldehyde and studied as selective fluorescence turn-off sensing towards Cu2+ ions in aqueous media. S1 demonstrated fluorescence turn-off… read more here.
Keywords: detection; fluorescence; novel highly; towards cu2 ... See more keywords
Novel, highly potent and in vivo active inhibitor of GABA transporter subtype 1 with anticonvulsant, anxiolytic, antidepressant and antinociceptive properties
Sign Up to like & getrecommendations! Published in 2017 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2016.10.019
Abstract: Background and purpose: Since GABAergic dysfunction underlies a variety of neurological and psychiatric disorders, numerous strategies leading to the augmentation of GABAergic neurotransmission have been introduced. One of them is the inhibition of GABA reuptake… read more here.
Keywords: highly potent; ddpm 2571; inhibitor; antidepressant ... See more keywords
Synthesis of CeO2/Au/Ho nanostructures as novel and highly efficient visible light driven photocatalyst
Sign Up to like & getrecommendations! Published in 2018 at "Separation and Purification Technology"
DOI: 10.1016/j.seppur.2017.08.008
Abstract: Abstract Only 3–5% of the UV photon flux reaching the earth’s surface, therefore it would be hugely beneficial to extend the light absorption of CeO2 to the visible light region. The present work is focused… read more here.
Keywords: ceo2 nanostructures; visible light; novel highly; ceo2 ... See more keywords
Discovery of SPH3127: A Novel, Highly Potent, and Orally Active Direct Renin Inhibitor.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00834
Abstract: Renin is the rate-limiting enzyme in the renin-angiotensin-aldosterone system (RAAS) which regulates blood pressure and renal function and hence is an attractive target for the treatment of hypertension and cardiovascular/renal diseases. However, the development of… read more here.
Keywords: highly potent; direct renin; novel highly; discovery sph3127 ... See more keywords
Novel and Highly Active Potassium Niobate-Based Photocatalyst for Dramatically Enhanced Hydrogen Production
Sign Up to like & getrecommendations! Published in 2018 at "ACS Sustainable Chemistry & Engineering"
DOI: 10.1021/acssuschemeng.8b00908
Abstract: A novel and highly active photocatalytic material, self-doped potassium niobate composite microflowers stimulated by noble-metal-free copper nanoparticles (Cu/K4Nb6O17), was achieved. The composition and structure of the composite microflowers were characterized by X-ray diffraction (XRD), high… read more here.
Keywords: hydrogen; potassium niobate; composite microflowers; novel highly ... See more keywords
CaFe2O4@SiO2-Cu as a novel and highly efficient nanocatalyst for direct conversion of epoxides to β-acetoxy esters
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-77281-1
Abstract: Direct conversion of structurally various epoxides to the related β-acetoxy esters was investigated using catalytic amounts of CaFe2O4@SiO2-Cu. The reactions were accomplished in the presence of acetic anhydride under solvent-free conditions within 0.5–2 h to… read more here.
Keywords: direct conversion; sio2 novel; acetoxy esters; cafe2o4 sio2 ... See more keywords
1,1,2-Tribromoethyl arenes: novel and highly efficient precursors for the synthesis of 1-bromoalkynes and α-bromoketones
Sign Up to like & getrecommendations! Published in 2021 at "Organic Chemistry Frontiers"
DOI: 10.1039/d1qo00793a
Abstract: A novel tribromination method to prepare versatile intermediate 1,1,2-tribromoethyl arenes, which can not only be transformed to synthetically valuable 1-bromoalkynes via elimination but also be hydrolyzed to a variety of α-bromoketones, was developed. read more here.
Keywords: tribromoethyl arenes; novel highly; arenes novel; efficient precursors ... See more keywords
Dual role of novel highly efficient radical generators for UV/LED-activated polymerization processes
Sign Up to like & getrecommendations! Published in 2025 at "Polymer Chemistry"
DOI: 10.1039/d5py00173k
Abstract: This study reports novel diphenyliodonium tosylates (IODs) as highly effective photoinitiators for the radical polymerization of (meth)acrylates. read more here.
Keywords: dual role; role novel; highly efficient; polymerization ... See more keywords
A Novel Highly Efficient Torque-Sharing Algorithm for Dual Stator Winding Induction Machines for Various Speed Regions
Sign Up to like & getrecommendations! Published in 2024 at "IEEE Transactions on Industrial Electronics"
DOI: 10.1109/tie.2023.3286002
Abstract: This article proposes a novel and highly efficient torque-sharing algorithm for dual stator winding induction machines (DSWIMs). This algorithm introduces three modes of operation for DSWIMs based on the command speed and the required load… read more here.
Keywords: torque sharing; speed regions; speed; highly efficient ... See more keywords