Design and Synthesis of Novel HIV-1 NNRTIs with Bicyclic Cores and with Improved Physicochemical Properties
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.2c01574
Abstract: Non-nucleoside reverse transcriptase inhibitors (NNRTIs) represent cornerstones of current regimens for treatment of human immunodeficiency virus type 1 (HIV-1) infections. However, NNRTIs usually suffer from low aqueous solubility and the emergence of resistant viral strains.… read more here.
Keywords: design synthesis; hiv; nnrtis; hiv nnrtis ... See more keywords
Characterization of a novel HIV-1 circulating recombinant form, CRF91_cpx, comprising CRF02_AG, G, J, and U, mostly among men who have sex with men
Sign Up to like & getrecommendations! Published in 2022 at "Virulence"
DOI: 10.1080/21505594.2022.2106021
Abstract: ABSTRACT Prospective molecular studies of HIV-1 pol region (2253–5250 in HXB2 genome) sequences from sequenced samples of 269 HIV-1-infected patients in Cyprus (2017–2021) revealed a transmission cluster of 14 unknown HIV-1 recombinants that were not… read more here.
Keywords: crf91 cpx; recombination; novel hiv; hiv ... See more keywords
Genomic Characterization of a Novel HIV-1 Second-Generation recombinant form (CRF01_AE/B) From a Men Who Have Sex with Men in Guangxi Zhuang Autonomous Region, China.
Sign Up to like & getrecommendations! Published in 2019 at "AIDS research and human retroviruses"
DOI: 10.1089/aid.2019.0149
Abstract: We report here a novel HIV-1 recombinant form (18GXD4705) composed of CRF01_AE and subtype B, acquired from an unmarried HIV-positive young-man subject infected through homosexual contact in Guangxi province of eastern China. The phylogenetic analysis… read more here.
Keywords: novel hiv; crf01; recombinant form; region ... See more keywords
Near Full-Length Genomic Characterization of a Novel HIV-1 Circulating Recombinant Form (CRF107_01B) Identified among Men Who Have Sex with Men in Heilongjiang province of China.
Sign Up to like & getrecommendations! Published in 2020 at "AIDS research and human retroviruses"
DOI: 10.1089/aid.2020.0159
Abstract: We reported a novel HIV-1 circulating recombinant form among four epidemiologically unlinked patients through men having sex with men (MSM) in HeiLongjiang Province, China. It was named CRF107_01B (this is temporary as we have not… read more here.
Keywords: hiv circulating; recombinant form; hiv; crf107 01b ... See more keywords
Near Full-Length Genomic Characterization of a Novel HIV-1 Unique Recombinant (A1/D/K) from an Immigrant Worker in China Using Nanopore Sequencing
Sign Up to like & getrecommendations! Published in 2025 at "AIDS Research and Human Retroviruses"
DOI: 10.1089/aid.2024.0108
Abstract: Recombination contributes substantially to the genetic diversity of HIV-1. Here we reported a novel HIV-1 recombinant detected from a Chinese labor who had been to Uganda as an immigrant worker using nanopore sequencing. Near full-length… read more here.
Keywords: hiv; novel hiv; using nanopore; immigrant worker ... See more keywords
Characterization of Two Novel HIV-1B/CRF01_AE/CRF07_BC Recombinant Forms Among Men Who Have Sex with Men in Hebei Province, China.
Sign Up to like & getrecommendations! Published in 2025 at "AIDS research and human retroviruses"
DOI: 10.1177/08892229251374704
Abstract: The frequent recombination between subtypes has driven significant HIV-1 genetic diversity in recent years, especially in some areas with co-circulation of multiple subtypes. In this study, we obtained nearly full-length genome sequences of two novel… read more here.
Keywords: characterization two; novel hiv; crf07; hiv crf01 ... See more keywords
First Identification of a Novel HIV-1 CRF80_0107/B Recombinant Form Among Men Who Have Sex with Men in Hebei Province, China.
Sign Up to like & getrecommendations! Published in 2025 at "AIDS research and human retroviruses"
DOI: 10.1177/08892229251378021
Abstract: The emergence of CRF80_0107 resulted from recombination between co-circulating CRF01_AE and CRF07_BC genotypes. To date, no secondary recombinants involving CRF80_0107 as a parental strain have been documented in public sequence databases. Here, we report the… read more here.
Keywords: 0107 recombinant; novel hiv; crf80 0107; hiv crf80 ... See more keywords
Characterization of a novel HIV-1 unique recombinant form between CRF07_BC and CRF55_01B in men who have sex with men in Guangzhou, China
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0175770
Abstract: Here, we report the genetic diversity of HIV-1 and emergence of novel HIV-1 unique recombinant forms (URF) in both HIV-infected intravenous drug users (IDU) and men who have sex with men (MSM) in Guangzhou, China.… read more here.
Keywords: hiv unique; crf55 01b; crf07 crf55; novel hiv ... See more keywords
Humanized Mice for the Evaluation of Novel HIV-1 Therapies
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.636775
Abstract: With the discovery of antiretroviral therapy, HIV-1 infection has transitioned into a manageable but chronic illness, which requires lifelong treatment. Nevertheless, complete eradication of the virus has still eluded us. This is partly due to… read more here.
Keywords: novel; evaluation novel; novel hiv; hiv ... See more keywords
Discovery of Novel HIV Protease Inhibitors Using Modern Computational Techniques
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232012149
Abstract: The human immunodeficiency virus type 1 (HIV-1) has continued to be a global concern. With the new HIV incidence, the emergence of multi-drug resistance and the untoward side effects of currently used anti-HIV drugs, there… read more here.
Keywords: hiv; hiv protease; protease inhibitors; modern computational ... See more keywords