Synthesis and Antitumor Evaluation of Novel Hybrids of Phenylsulfonylfuroxan and Estradiol Derivatives
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DOI: 10.1002/open.201900228
Abstract: Abstract Fifteen novel furoxan‐based nitric oxide (NO) releasing hybrids of estradiol derivatives were synthesized and evaluated in vitro anti‐proliferative activity in MDA‐MB‐231, A2780, Hela and HUVEC cell lines. Most of them displayed potent anti‐proliferative effects. Among… read more here.
Keywords: antitumor evaluation; novel hybrids; estradiol derivatives; evaluation novel ... See more keywords
Novel Hybrids of 6-Amino-3-n-butylphthalide and Neuroprotective Groups against Ischemic Stroke
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DOI: 10.1039/d4nj01760a
Abstract: Ischemic stroke (IS) is the leading cause of disability and the second most common cause of death in adult globally. Unfortunately, recombinant tissue plasminogen activator (rt-PA), the only thrombolytic drug... read more here.
Keywords: ischemic stroke; novel hybrids; butylphthalide neuroprotective; amino butylphthalide ... See more keywords
Novel Hybrids of Podophyllotoxin and Coumarin Inhibit the Growth and Migration of Human Oral Squamous Carcinoma Cells
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DOI: 10.3389/fchem.2020.626075
Abstract: Oral squamous cell carcinoma is the most common malignancy of oral tumor. In this study, two novel hybrids of podophyllotoxin and coumarin were designed using molecular hybridization strategy and synthesized. Pharmacological evaluation showed that the… read more here.
Keywords: novel hybrids; carcinoma; hybrids podophyllotoxin; podophyllotoxin coumarin ... See more keywords