Synthesis and anticancer properties of novel hydrazone derivatives incorporating pyridine and isatin moieties
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DOI: 10.1002/ardp.202000377
Abstract: Nine novel hydrazone derivatives (4a–i) incorporating pyridine and isatin moieties were synthesized through one‐pot, four‐component heterocyclic condensation reactions. The structures of all new compounds (2a–e, 3a, 3c–e, and 4a–e) were identified by 1H nuclear magnetic… read more here.
Keywords: novel hydrazone; hydrazone derivatives; incorporating pyridine; log ic50 ... See more keywords
Synthesis of Novel Cu(II), Co(II), Fe(II), and Ni(II) Hydrazone Metal Complexes as Potent Anticancer Agents: Spectroscopic, DFT, Molecular Docking, and MD Simulation Studies
Sign Up to like & getrecommendations! Published in 2024 at "ACS Omega"
DOI: 10.1021/acsomega.4c06202
Abstract: Metal complexes [FeL], [NiL]·H2O, [CuL], and [CoL]·H2O were formed by the ligand (L, 4-fluoro-N′-(2-hydroxybenzylidene)benzohydrazide) reacting with Fe(OAc)2, Ni(OAc)2·4H2O, Cu(OAc)2·H2O, and Co(OAc)2·4H2O. The produced compounds were characterized using a variety of methods, such as NMR, UV–vis,… read more here.
Keywords: molecular docking; synthesis novel; novel hydrazone; metal ... See more keywords
Novel hydrazone compounds with broad-spectrum antiplasmodial activity and synergistic interactions with antimalarial drugs
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DOI: 10.1128/aac.01643-23
Abstract: ABSTRACT The development of novel antiplasmodial compounds with broad-spectrum activity against different stages of Plasmodium parasites is crucial to prevent malaria disease and parasite transmission. This study evaluated the antiplasmodial activity of seven novel hydrazone… read more here.
Keywords: broad spectrum; compounds broad; novel hydrazone; antiplasmodial activity ... See more keywords
mTOR Pathway Inhibition, Anticancer Activity and In Silico Calculations of Novel Hydrazone Derivatives in Two- and Three-Dimensional Cultured Type 1 Endometrial Cancer Cells
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DOI: 10.3390/ph17121562
Abstract: Background: Endometrial cancer remains a significant health concern, with type 1 endometrial cancer characterized by aberrant expression of estrogen-dependent and mTOR pathway proteins. In this study, we evaluated the effects of two novel hydrazone derivatives… read more here.
Keywords: hydrazone derivatives; novel hydrazone; anticancer activity; endometrial cancer ... See more keywords