Discovery of Novel N-Hydroxy-1,2,4-oxadiazole-5-formamides as ASM Direct Inhibitors for the Treatment of Atherosclerosis.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01643
Abstract: Acid sphingomyelinase (ASM), which regulates sphingolipid metabolism and lipid signaling, has been considered as a new potential target for the treatment of atherosclerosis. In this study, a series of benzene-heterocyclic-based ASM inhibitors were rationally designed,… read more here.
Keywords: discovery novel; novel hydroxy; asm; atherosclerosis ... See more keywords
Synthesis, spectral analysis, quantum studies, NLO, and thermodynamic properties of the novel 5-(6-hydroxy-4-methoxy-1-benzofuran-5-ylcarbonyl)-6-amino-3-methyl-1H-pyrazolo[3,4-b] pyridine (HMBPP)
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DOI: 10.1039/d2ra01469f
Abstract: Ring opening followed by ring closure reactions of 4-methoxy-5-oxo-5H-furo[3,2-g] chromene-6-carbonitrile (1) with 5-amino-3-methyl-1H-pyrazole (2) afforded the novel 5-(6-hydroxy-4-methoxy-1-benzofuran-5-ylcarbonyl)-6-amino-3-methyl-1H-pyrazolo[3,4-b] pyridine (3, HMBPP). The chemical structure of the synthesized compound was established based on elemental analysis and… read more here.
Keywords: novel hydroxy; amino methyl; hydroxy methoxy; analysis ... See more keywords
Synthesis of novel 3-hydroxy-2-naphthoic hydrazones as selective chemosensors for cyanide ions
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DOI: 10.1039/d3ra00788j
Abstract: The development of an effective and selective chemosensor for CN− ions has become the need of the hour due to their hazardous impact on the environment and humans. Herein, we report the synthesis of two… read more here.
Keywords: novel hydroxy; hydrazones selective; hydroxy naphthoic; naphthoic hydrazones ... See more keywords
Design, synthesis and biological evaluation of novel hydroxy-phenyl-1H-benzimidazoles as radical scavengers and UV-protective agents
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DOI: 10.1080/14756366.2016.1265523
Abstract: Abstract An ever-increasing incidence of skin neoplastic diseases is registered. Therefore, it is important to protect the skin from the UV radiation that reaches the epidermis and dermis but also to block ROS generated by… read more here.
Keywords: design synthesis; evaluation novel; biological evaluation; phenyl ... See more keywords