Novel hypoxia-targeting Pt(iv) prodrugs.
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DOI: 10.1039/c7cc01320e
Abstract: Novel Pt(iv) prodrugs targeting hypoxia inducible factor HIF-1α were prepared for evaluating their antitumor activity on hypoxic cancer cells for the first time. The resulting Pt(iv) prodrug exhibited effective inhibition on tumor growth in the… read more here.
Keywords: targeting prodrugs; novel hypoxia; hypoxia targeting;
Identification of Novel Hypoxia Subtypes for Prognosis Based on Machine Learning Algorithms
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DOI: 10.1155/2022/1508113
Abstract: Objective A reduced level or tension or the deprivation of oxygen is termed hypoxia. It is common for tumours to outgrow their natural source of nutrients, which causes hypoxia in some tumour regions. Hypoxia affects… read more here.
Keywords: hypoxia subtypes; hypoxia; prognosis based; novel hypoxia ... See more keywords
A Boolean approach for novel hypoxia-related gene discovery
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DOI: 10.1371/journal.pone.0273524
Abstract: Hypoxia plays a major role in the etiology and pathogenesis of most of the leading causes of morbidity and mortality, whether cardiovascular diseases, cancer, respiratory diseases or stroke. Despite active research on hypoxia-signaling pathways, the… read more here.
Keywords: gene; hypoxia; hypoxia related; novel hypoxia ... See more keywords
A Novel Hypoxia Related Marker in Blood Link to Aid Diagnosis and Therapy in Osteoarthritis
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DOI: 10.3390/genes13091501
Abstract: Osteoarthritis (OA) is a common chronic degenerative arthritis. Its treatment options are very limited. At present, hypoxia is a prominent factor in OA. This study aimed to re-explore the mechanism between hypoxia and OA, which… read more here.
Keywords: diagnosis; osteoarthritis; hypoxia; hypoxia related ... See more keywords