Identification of novel imidazole flavonoids as potent and selective inhibitors of protein tyrosine phosphatase.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.03.074
Abstract: A series of imidazole flavonoids as new type of protein tyrosine phosphatase inhibitors were synthesized and characterized. Most of them gave potent protein phosphatase 1B (PTP1B) inhibitory activities. Especially, compound 11a could effectively inhibit PTP1B… read more here.
Keywords: imidazole flavonoids; phosphatase; tyrosine phosphatase; protein tyrosine ... See more keywords
Novel imidazole-alkyl spacer-carbazole based fluorophores for deep-blue organic light emitting diodes: Experimental and theoretical investigation
Sign Up to like & getrecommendations! Published in 2021 at "Dyes and Pigments"
DOI: 10.1016/j.dyepig.2020.108853
Abstract: Abstract A series of fluorescent emitters based on Imidazole-Alkyl spacer-Carbazole were designed and synthesized by connecting donor and acceptor moieties through alkyl spacer. In these design strategy we have chosen carbazole as electron rich and… read more here.
Keywords: spacer; imidazole alkyl; spacer carbazole; novel imidazole ... See more keywords
A Novel Imidazole-Core-Based Benzoxazine and Its Blends for High-Performance Applications
Sign Up to like & getrecommendations! Published in 2017 at "Industrial & Engineering Chemistry Research"
DOI: 10.1021/acs.iecr.7b01816
Abstract: In the present work, a novel imidazole-core-based bisphenol (IBP) was synthesized and characterized. The IBP and formaldehyde were reacted separately with aniline and N,N-dimethylaminopropylamine (DMAPA) under appropriate conditions to obtain benzoxazines, which were characterized for… read more here.
Keywords: imidazole core; novel imidazole; based benzoxazine; core based ... See more keywords
Novel Imidazole Phenoxyacetic Acids as Inhibitors of USP30 for Neuroprotection Implication via the Ubiquitin-Rho-110 Fluorometric Assay: Design, Synthesis, and In Silico and Biochemical Assays.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.2c00076
Abstract: USP30, a deubiquitinating enzyme family, forfeits the ubiquitination of E3 ligase and Parkin on the surface of mitochondria. Inhibition of USP30 results in mitophagy and cellular clearance. Herein, by understanding structural requirements, we discovered potential… read more here.
Keywords: synthesis; novel imidazole; fluorometric assay; 110 fluorometric ... See more keywords
Insight into the Structure and Properties of Novel Imidazole-Based Salts of Salicylic Acid
Sign Up to like & getrecommendations! Published in 2019 at "Molecules"
DOI: 10.3390/molecules24224144
Abstract: The preparation of new active pharmaceutical ingredient (API) multicomponent crystal forms, especially co-crystals and salts, is being considered as a reliable strategy to improve API solubility and bioavailability. In this study, three novel imidazole-based salts… read more here.
Keywords: salicylic acid; insight structure; imidazole based; based salts ... See more keywords
Novel Imidazole Liquid Crystals; Experimental and Computational Approaches
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27144607
Abstract: The liquid crystalline materials named (E)-4-(2-(4-oxo-5,5-diphenyl-4,5-dihydro-1H-imidazol-2-yl)hydrazineylidene)methyl)phenyl and 4-(alkoxy)benzoate, In, were synthesized and their mesomorphic behaviors were examined. The chemical structures of the produced compounds were confirmed by Fourier-transform infrared spectroscopy (FT-IR), NMR, and elemental analysis.… read more here.
Keywords: crystals experimental; experimental computational; computational approaches; liquid crystals ... See more keywords