Targeting vascular inflammation in ischemic stroke: Recent developments on novel immunomodulatory approaches
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2018.06.028
Abstract: Abstract Ischemic stroke is a devastating and debilitating medical condition with limited therapeutic options. However, accumulating evidence indicates a central role of inflammation in all aspects of stroke including its initiation, the progression of injury,… read more here.
Keywords: ischemic stroke; recent developments; inflammation; immunomodulatory approaches ... See more keywords
A Phase I study of the novel immunomodulatory agent PG545 (pixatimod) in subjects with advanced solid tumours
Sign Up to like & getrecommendations! Published in 2018 at "British Journal of Cancer"
DOI: 10.1038/s41416-018-0006-0
Abstract: BackgroundPG545 (pixatimod) is a novel immunomodulatory agent, which has been demonstrated to stimulate innate immune responses against tumours in preclinical cancer models.MethodsThis Phase I study investigated the safety, tolerability, pharmacokinetics, pharmacodynamics and preliminary efficacy of… read more here.
Keywords: immunomodulatory agent; advanced solid; pixatimod; phase study ... See more keywords
P013 Novel immunomodulatory role of food bioactive peptide lunasin in the healthy human intestinal mucosa
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Crohn's and Colitis"
DOI: 10.1093/ecco-jcc/jjy222.137
Abstract: Resumen del trabajo presentado al 14th Congress of European Crohn's and Colitis Organisation (ECCO), celebrado en Copenague (Dinamarca) del 6 al 9 de marzo de 2019. read more here.
Keywords: role food; novel immunomodulatory; food bioactive; p013 novel ... See more keywords
An open-label, multi-center phase I study of the safety and tolerability of the novel immunomodulatory agent PG545 in subjects with advanced solid tumors.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.15_suppl.3083
Abstract: 3083Background: PG545 (pixatimod, pINN) is a novel immunomodulatory agent which stimulates dendritic cells (DC) via TLR9/IL-12 pathway to activate natural killer (NK) cells. It also inhibits tumour... read more here.
Keywords: open label; immunomodulatory agent; novel immunomodulatory; label multi ... See more keywords
Examination of Novel Immunomodulatory Effects of L-Sulforaphane
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DOI: 10.3390/nu13020602
Abstract: The dietary isothiocyanate L-sulforaphane (LSF), derived from cruciferous vegetables, is reported to have several beneficial biological properties, including anti-inflammatory and immunomodulatory effects. However, there is limited data on how LSF modulates these effects in human… read more here.
Keywords: lsf; examination novel; effects sulforaphane; immunomodulatory effects ... See more keywords