Selective cytotoxicity of a novel immunotoxin based on pulchellin A chain for cells expressing HIV envelope
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-08037-3
Abstract: Immunotoxins (ITs), which consist of antibodies conjugated to toxins, have been proposed as a treatment for cancer and chronic infections. To develop and improve the ITs, different toxins such as ricin, have been used, aiming… read more here.
Keywords: selective cytotoxicity; pulchellin; novel immunotoxin; immunotoxin based ... See more keywords
A phase I study of the novel immunotoxin, MT-5111, in subjects (subj) with HER-2 positive tumors: Interim results.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.15_suppl.e15567
Abstract: e15567Background: Engineered toxin bodies (ETBs), composed of a Shiga-like Toxin A subunit genetically fused to antibody-like binding domains, can force receptor internalization, self-route through... read more here.
Keywords: study novel; 5111 subjects; immunotoxin 5111; subjects subj ... See more keywords