Design, synthesis, biological evaluation and docking study of novel indole-2-amide as anti-inflammatory agents with dual inhibition of COX and 5-LOX.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.07.004
Abstract: In this work, a series of novel indole-2-amide compounds were designed, synthesized, characterized and the anti-inflammatory activity in vivo were evaluated. Compounds 8a, 10b, 12h, and 12l exhibited marked anti-inflammatory activity in 2,4-Dinitrofluorobenzenethe (DNFB) - induced… read more here.
Keywords: anti inflammatory; novel indole; indole amide; lox ... See more keywords
The novel Indole‐3‐formaldehyde (2‐AITFEI‐3‐F) is involved in processes of apoptosis induction?
Sign Up to like & getrecommendations! Published in 2017 at "Life Sciences"
DOI: 10.1016/j.lfs.2017.05.026
Abstract: Aim and objectives: Balancing between Bax and Bcl‐2 plays critical roles in both proliferation and self‐renewal activation of cancer cells. Indole‐3‐formaldehyde derivatives limit the growth and facilitate cell death in different cell systems. In this… read more here.
Keywords: novel indole; apoptosis; indole formaldehyde; aitfei ... See more keywords
The novel indole glucoalkaloid and secoiridoid glucoside from Tripterospermum chinense
Sign Up to like & getrecommendations! Published in 2020 at "Phytochemistry Letters"
DOI: 10.1016/j.phytol.2019.12.005
Abstract: Abstract Tripterospermumcin F (1), a novel indole glucoalkaloid, and tripterospermumcin G (2), a new iridoid tetramer, were isolated from the aerial parts of Tripterospermum chinense. Their structures were determined by analysis of 1D and 2D… read more here.
Keywords: novel indole; secoiridoid glucoside; tripterospermum chinense; glucoalkaloid secoiridoid ... See more keywords
Synthesis, Antibacterial Activity, and Mechanisms of Novel Indole Derivatives Containing Pyridinium Moieties.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c04213
Abstract: The development of effective antibacterial agents equipped with novel action modes and unique skeletons starting from natural compounds serves as an important strategy in the modern pesticide industry. Disclosed here are a series of novel… read more here.
Keywords: antibacterial activity; novel indole; indole derivatives; derivatives containing ... See more keywords
X-ray Crystal Structure-Guided Discovery of Novel Indole Analogues as Colchicine-Binding Site Tubulin Inhibitors with Immune-Potentiating and Antitumor Effects against Melanoma.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.3c00011
Abstract: A series of novel indole analogues were discovered as colchicine-binding site inhibitors of tubulin. Among them, 3a exhibited the highest antiproliferative activity (average IC50 = 4.5 nM), better than colchicine (IC50 = 65.3 nM). The… read more here.
Keywords: tubulin; indole analogues; novel indole; crystal structure ... See more keywords
Synthesis and Anticancer Evaluation of Novel Indole Based Arylsulfonylhydrazides against Human Breast Cancer Cells
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c03908
Abstract: A series of novel indole based sulfonohydrazide derivatives (5a–k) containing morpholine heterocyclic ring were synthesized through multistep chemical reactions. The target compounds (5a–k) were prepared by the reaction of substituted phenyl sulfonylhydrazides (2a–k) with morpholine… read more here.
Keywords: breast cancer; novel indole; cancer; indole based ... See more keywords
Novel indole based hybrid oxadiazole scaffolds with: N -(substituted-phenyl)butanamides: Synthesis, lineweaver-burk plot evaluation and binding analysis of potent urease inhibitors
Sign Up to like & getrecommendations! Published in 2018 at "RSC Advances"
DOI: 10.1039/c8ra04987d
Abstract: In the study presented herein, 4-(1H-indol-3-yl)butanoic acid (1) was sequentially transformed in the first phase into ethyl 4-(1H-indol-3-yl)butanoate (2), 4-(1H-indol-3-yl)butanohydrazide (3) and 5-[3-(1H-indol-3-yl)propyl]-1,3,4-oxadiazole-2-thiol (4) as a nucleophile. In the second phase, various electrophiles were synthesized… read more here.
Keywords: oxadiazole scaffolds; novel indole; scaffolds substituted; substituted phenyl ... See more keywords
Synthesis, characterization, and in vitro anti-cholinesterase screening of novel indole amines
Sign Up to like & getrecommendations! Published in 2023 at "RSC Advances"
DOI: 10.1039/d2ra05105b
Abstract: The present study involved the targeted synthesis and characterization of novel indole amines with anti-acetylcholinesterase profiling. A series of proposed indole amines was virtually screened against human acetylcholinesterase. A few indole amines (23, 24, and… read more here.
Keywords: synthesis characterization; novel indole; indole amines; acetylcholinesterase ... See more keywords
Corrigendum: Synthesis and Cytotoxic Activity of Novel Indole Derivatives and Their in silico Screening on Spike Glycoprotein of SARS-CoV-2
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2021.716238
Abstract: [This corrects the article DOI: 10.3389/fmolb.2021.637989.]. read more here.
Keywords: corrigendum synthesis; novel indole; activity novel; indole derivatives ... See more keywords
A Novel Indole Derivative with Superior Photophysical Performance for Fluorescent Probe, pH-Sensing, and Logic Gates
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24021711
Abstract: An indole-related molecules have been considered as the potential fluorescent probes for biological and electrochemical sensing. However, most of the indole probes have been usually used in a single detection mode. Indolium probes that enable… read more here.
Keywords: logic gates; superior photophysical; novel indole; indole derivative ... See more keywords
Synthesis of Novel Indole Schiff Base Compounds and Their Antifungal Activities
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27206858
Abstract: A series of novel indole Schiff base derivatives (2a–2t) containing a 1,3,4-thiadiazole scaffold modified with a thioether group were synthesized, and their structures were confirmed using FT-IR, 1H NMR, 13C NMR, and HR-MS. In addition,… read more here.
Keywords: synthesis novel; indole schiff; novel indole; schiff base ... See more keywords