Dynarrestin, a Novel Inhibitor of Cytoplasmic Dynein.
Sign Up to like & getrecommendations! Published in 2018 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2017.12.014
Abstract: Aberrant hedgehog (Hh) signaling contributes to the pathogenesis of multiple cancers. Available inhibitors target Smoothened (Smo), which can acquire mutations causing drug resistance. Thus, compounds that inhibit Hh signaling downstream of Smo are urgently needed.… read more here.
Keywords: inhibitor cytoplasmic; dynein; novel inhibitor; cytoplasmic dynein ... See more keywords
LncRNA expression profiles in HBV‐transformed human hepatocellular carcinoma cells treated with a novel inhibitor of human La protein
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Viral Hepatitis"
DOI: 10.1111/jvh.12821
Abstract: We previously identified a novel inhibitor of La protein, H11, which inhibited hepatitis B virus (HBV) replication by inhibiting the interaction between La protein and HBV RNA. However, the other cellular factors involved in this… read more here.
Keywords: protein; analysis; hbv; novel inhibitor ... See more keywords
NIO-1, a novel inhibitor of OCT1, enhances the antitumor action of radiofrequency ablation against hepatocellular carcinoma.
Sign Up to like & getrecommendations! Published in 2023 at "Current molecular medicine"
DOI: 10.2174/1566524023666230526154739
Abstract: BACKGROUND Radiofrequency ablation (RFA) is an important treatment strategy for patients with advanced hepatocellular carcinoma (HCC). However, its therapeutic effect is unsatisfactory and recurrence often occurs after RFA treatment. The octamer-binding transcription factor OCT1 is… read more here.
Keywords: hepatocellular carcinoma; nio; novel inhibitor; rfa ... See more keywords
Multi-Targeting Andrographolide, a Novel NF-κB Inhibitor, as a Potential Therapeutic Agent for Stroke
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms18081638
Abstract: A key focus in the field of drug discovery has been motivated by the neuroprotection of natural compounds. Cerebral ischemia is a multifaceted pathological process with a series of mechanisms, and a perspective for the… read more here.
Keywords: multi targeting; novel inhibitor; inhibitor potential; potential therapeutic ... See more keywords