Novel Insights and Perspectives for the Diagnosis and Treatment of Hearing Loss through the Implementation of Magnetic Nanotheranostics
Sign Up to like & getrecommendations! Published in 2022 at "ChemMedChem"
DOI: 10.1002/cmdc.202100685
Abstract: Hearing loss (HL) is a sensory disability that affects 5 % of the world‘s population. HL predominantly involves damage and death to the cochlear cells. Currently, there is no cure or specific medications for HL. Furthermore,… read more here.
Keywords: diagnosis treatment; hearing loss; loss; perspectives diagnosis ... See more keywords
Novel insights on [1,2]oxazolo[5,4‐e]isoindoles on multidrug resistant acute myeloid leukemia cell line
Sign Up to like & getrecommendations! Published in 2022 at "Drug Development Research"
DOI: 10.1002/ddr.21962
Abstract: A series of [1,2]oxazolo[5,4‐e]isoindole derivatives was evaluated against HL‐60 cell line and its multidrug resistance (MDR) variant, HL‐60R, resistant to doxorubicin and to other P‐gp substrates by overexpressing the efflux pump. They displayed antiproliferative activities,… read more here.
Keywords: cell; cell line; oxazolo isoindoles; insights oxazolo ... See more keywords
Novel insights for the role of nitric oxide in placental vascular function during and beyond pregnancy.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cellular physiology"
DOI: 10.1002/jcp.30470
Abstract: More than 30 years have passed since endothelial nitric oxide synthesis was described using the umbilical artery and vein endothelium. That seminal report set the cornerstone for unveiling the molecular aspects of endothelial function. In… read more here.
Keywords: pregnancy; nitric oxide; physiology; novel insights ... See more keywords
Human adaptation to immobilization: Novel insights of impacts on glucose disposal and fuel utilization
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cachexia, Sarcopenia and Muscle"
DOI: 10.1002/jcsm.13075
Abstract: Bed rest (BR) reduces whole‐body insulin‐stimulated glucose disposal (GD) and alters muscle fuel metabolism, but little is known about metabolic adaptation from acute to chronic BR nor the mechanisms involved, particularly when volunteers are maintained… read more here.
Keywords: adaptation; glucose disposal; human adaptation; adaptation immobilization ... See more keywords
Novel insights into the role of circular RNAs in Parkinson disease: An emerging renaissance in the management of neurodegenerative diseases
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.25094
Abstract: Parkinson's disease (PD), as a debilitating neurodegenerative disease, particularly affects the elderly population, and is clinically identified by resting tremor, rigidity, and bradykinesia. Pathophysiologically, PD is characterized by an early loss of dopaminergic neurons in… read more here.
Keywords: disease; circular rnas; parkinson disease; insights role ... See more keywords
Novel insights into conceptus-maternal signaling during pregnancy establishment in pigs.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular reproduction and development"
DOI: 10.1002/mrd.23567
Abstract: Pregnancy establishment in mammals, including pigs, requires coordinated communication between developing conceptuses (embryos with associated membranes) and the maternal organism. Porcine conceptuses signalize their presence by secreting multiple factors, of which estradiol-17β (E2) is considered… read more here.
Keywords: insights conceptus; pregnancy establishment; pregnancy; conceptus maternal ... See more keywords
From plants to herbivores: novel insights into the ecological and evolutionary consequences of plant variation
Sign Up to like & getrecommendations! Published in 2018 at "Oecologia"
DOI: 10.1007/s00442-018-4126-2
Abstract: Individuals differ! This observation goes already back to Aristotle almost 2500 years ago, but individual differences are nowadays still highlighted in various areas of social and natural sciences. Almost every day, new fascinating layers of… read more here.
Keywords: variation; plants herbivores; plant; plant variation ... See more keywords
Novel insights into cerebral palsy
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Muscle Research and Cell Motility"
DOI: 10.1007/s10974-020-09577-4
Abstract: Cerebral palsy (CP) is a neurodevelopmental disorder characterized by abnormalities of muscle tone, movement and motor skills, and is attributed to injury to the developing brain. CP affects about 1 in 500 neonates. CP shows… read more here.
Keywords: collagen; cerebral palsy; insights cerebral; palsy ... See more keywords
The wonder exerkines-novel insights: a critical state-of-the-art review.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular and cellular biochemistry"
DOI: 10.1007/s11010-021-04264-5
Abstract: Several benefits can be acquired through physical exercise. Different classes of biomolecules are responsible for the cross-talk between distant organs. The secretome of skeletal muscles, and more widely the field of organokines, is ever-expanding. "Exerkine"… read more here.
Keywords: novel insights; exerkines novel; review; exercise ... See more keywords
Novel insights into the calcium action in cherry fruit development revealed by high-throughput mapping.
Sign Up to like & getrecommendations! Published in 2020 at "Plant molecular biology"
DOI: 10.1007/s11103-020-01063-2
Abstract: KEY MESSAGE This work provides the first system-wide datasets concerning metabolic changes in calcium-treated fruits, which reveal that exogenously applied calcium may specifically reprogram sweet cherry development and ripening physiognomy. Calcium modulates a wide range… read more here.
Keywords: cherry fruit; fruit; novel insights; biology ... See more keywords
Novel insights in plasticity and learning impairments in Fragile X Syndrome.
Sign Up to like & getrecommendations! Published in 2021 at "Brain research bulletin"
DOI: 10.1016/j.brainresbull.2021.06.025
Abstract: The function of brain circuits relies on high-fidelity information transfer, precisely controlling integration of synaptic input, leading to neuronal output. Synaptic inputs arrive primarily at dendrites, where they undergo integration and summation throughout the somatodendritic… read more here.
Keywords: information; fragile syndrome; novel insights; plasticity learning ... See more keywords