Alternative splicing generates a novel ferroportin isoform with a shorter C‐terminal and an intact iron‐ and hepcidin‐binding property
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DOI: 10.1002/iub.2809
Abstract: Ferroportin (FPN) is a transmembrane protein and is the only known iron exporter that helps in maintaining iron homeostasis in vertebrates. To maintain stable iron equilibrium in the body, ferroportin works in conjunction with a… read more here.
Keywords: alternative splicing; iron; novel isoform; hepcidin ... See more keywords
A novel isoform of Tensin1 promotes actin filament assembly for efficient erythroblast enucleation.
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DOI: 10.1182/bloodadvances.2025016100
Abstract: Key Points • A novel short TNS1 isoform (eTNS1) with a unique primate-specific start exon 1E increases late in terminal erythroid differentiation.• CRISPR-associated protein 9 deletion of eTNS1 impairs F-actin assembly in orthochromatic erythroblasts and… read more here.
Keywords: filament assembly; tensin1 promotes; novel isoform; actin filament ... See more keywords