Novel γ-lactone derivatives from Trigonostemon heterophyllus with their potential antiproliferative activities.
Sign Up to like & getrecommendations! Published in 2018 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2018.04.015
Abstract: Two novel γ-lactone derivatives, trigoheterophines A (1) and B (2), together with four known furan derivatives (3-6), were isolated from the stems and leaves of Trigonostemon heterophyllus. The structures of 1 and 2 were elucidated… read more here.
Keywords: trigonostemon heterophyllus; novel lactone; lactone derivatives; antiproliferative activities ... See more keywords
Design and stereoselective synthesis of novel β-lactone and β-lactams as potent anticancer agents on breast cancer cells
Sign Up to like & getrecommendations! Published in 2018 at "Tetrahedron"
DOI: 10.1016/j.tet.2017.12.044
Abstract: Abstract To produce a novel class of anticancer compounds, an efficient method for synthesizing novel β-lactone and β-lactam frameworks was developed based on the reaction of a new ketene with C=O and C=N bonds. Functionalized… read more here.
Keywords: cancer cells; anticancer; novel lactone; breast cancer ... See more keywords