Unraveling novel mechanisms controlling heterosis in seeds: advances and biotechnological applications in crops
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Experimental Botany"
DOI: 10.1093/jxb/eraf400
Abstract: Abstract Heterosis refers to the superior performance of hybrids over their parents (inbred lines) in one or more characteristics. Hence, understanding this process is crucial for addressing food insecurity. This review explores the traditional genetic… read more here.
Keywords: controlling heterosis; seed; mechanisms controlling; novel mechanisms ... See more keywords
Novel mechanisms and clinical trial endpoints in intestinal fibrosis *
Sign Up to like & getrecommendations! Published in 2021 at "Immunological Reviews"
DOI: 10.1111/imr.12974
Abstract: The incidence of inflammatory bowel diseases (IBD) worldwide has resulted in a global public health challenge. Intestinal fibrosis leading to stricture formation and bowel obstruction is a frequent complication in Crohn's disease (CD), and the… read more here.
Keywords: clinical trial; novel mechanisms; intestinal fibrosis; fibrosis ... See more keywords
Novel Mechanisms Modulating Palmitate-Induced Inflammatory Factors in Hypertrophied 3T3-L1 Adipocytes by AMPK
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Diabetes Research"
DOI: 10.1155/2018/9256482
Abstract: Objective A growing body of evidence indicates that AMP-activated protein kinase (AMPK) contributes to not only energy metabolic homeostasis but also the inhibition of inflammatory responses. However, the underlying mechanisms remain unclear. To elucidate the… read more here.
Keywords: mcp release; novel mechanisms; 3t3 adipocytes; hypertrophied 3t3 ... See more keywords
Abstract 2039: Cellular characterization of small molecule PD-L1 inhibitors reveal their novel mechanisms of action
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-2039
Abstract: Introductions: Immune checkpoint inhibitors, including PD-1/L1, are key regulators of immune response and promising targets in cancer immunotherapy. Like anti-PD-1/L1 antibodies, small molecule PD-L1 inhibitors that have been discovered by us and others could also… read more here.
Keywords: cancer; mechanisms action; novel mechanisms; molecule inhibitors ... See more keywords
Dissecting novel mechanisms of hepatitis B virus-related hepatocellular carcinoma using meta-analysis of public data.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2021.39.3_suppl.333
Abstract: 333Background: Hepatitis B is a cause of hepatocellular carcinoma (HCC) globally, irrespective of viral loads. Interestingly, this process is not necessarily mediated through cirrhosis and may in f... read more here.
Keywords: hepatocellular carcinoma; carcinoma; hepatitis virus; mechanisms hepatitis ... See more keywords
Novel mechanisms of chemoresistance by Fusobacterium nucleatum involve not so novel pathways of microRNAs and autophagy
Sign Up to like & getrecommendations! Published in 2018 at "Translational cancer research"
DOI: 10.21037/tcr.2017.12.20
Abstract: Colon cancer is the second leading cause of cancer death among both men and women in the United States. Even with available chemotherapies, a significant number of patients have recurrent disease, leading to the high… read more here.
Keywords: chemoresistance fusobacterium; novel mechanisms; fusobacterium nucleatum; cancer ... See more keywords
Preeclampsia: Novel Mechanisms and Potential Therapeutic Approaches
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2018.00973
Abstract: Preeclampsia is a serious complication of pregnancy where it affects 5–8% of all pregnancies. It increases the morbidity and mortality of both the fetus and pregnant woman, especially in developing countries. It deleteriously affects several… read more here.
Keywords: preeclampsia novel; novel mechanisms; mechanisms potential; therapeutic approaches ... See more keywords
Spatial Transcriptomics Reveals Novel Mechanisms Involved in Perineural Invasion in Pancreatic Ductal Adenocarcinomas
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DOI: 10.3390/cancers17050852
Abstract: Simple Summary Pancreatic cancer has a low survival rate with limited treatment options. Perineural invasion (PNI), where cancer cells infiltrate the nerves in the pancreas, is associated with a poor prognosis and local recurrence. Pancreatic… read more here.
Keywords: cancer; spatial transcriptomics; mechanisms involved; perineural invasion ... See more keywords
The Unfolded Protein Response—Novel Mechanisms, Challenges, and Key Considerations for Therapeutic Intervention
Sign Up to like & getrecommendations! Published in 2025 at "Cancers"
DOI: 10.3390/cancers17223639
Abstract: Simple Summary The unfolded protein response is an intricate network of pathways that mediates intracellular and intercellular cancer cell fate. Previous works have focused mainly on the intracellular roles of UPR. Through a systematic review… read more here.
Keywords: response novel; novel mechanisms; unfolded protein; protein response ... See more keywords