Novel metabolic biomarker for early detection and diagnosis to the patients with gastric cardia adenocarcinoma
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Medicine"
DOI: 10.1002/cam4.7015
Abstract: Gastric cardia adenocarcinoma (GCA) is classified as Siewert type II adenocarcinoma at the esophagogastric junction in Western countries. The majority of GCA patients do not exhibit early warning symptoms, leading to over 90% of diagnoses… read more here.
Keywords: cardia adenocarcinoma; adenocarcinoma; gastric cardia; novel metabolic ... See more keywords
Mapping Novel Metabolic Nodes Targeted by Anti-Cancer Drugs that Impair Triple-Negative Breast Cancer Pathogenicity.
Sign Up to like & getrecommendations! Published in 2017 at "ACS chemical biology"
DOI: 10.1021/acschembio.6b01159
Abstract: Triple-negative breast cancers (TNBCs) are estrogen receptor, progesterone receptor, and HER2 receptor-negative subtypes of breast cancers that show the worst prognoses and lack targeted therapies. Here, we have coupled the screening of ∼400 anticancer agents… read more here.
Keywords: novel metabolic; negative breast; tnbc pathogenicity; pathogenicity ... See more keywords
Predicting novel metabolic pathways through subgraph mining
Sign Up to like & getrecommendations! Published in 2017 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btx481
Abstract: Motivation: The ability to predict pathways for biosynthesis of metabolites is very important in metabolic engineering. It is possible to mine the repertoire of biochemical transformations from reaction databases, and apply the knowledge to predict… read more here.
Keywords: novel metabolic; metabolic pathways; predicting novel; subgraph mining ... See more keywords
Abstract 2429: AGPAT4 as a novel metabolic driver of oncogenic stemness and dedifferentiation in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-2429
Abstract: The liver is an unique organ in that it is responsible for many metabolic functions. During HCC development, these metabolic machineries are extensively reprogrammed to support the insatiable nutrient requirement of HCC. Cancer stem cells… read more here.
Keywords: novel metabolic; hcc; agpat4; agpat4 novel ... See more keywords
Abstract 4154: Cancer cells exhibit novel metabolic vulnerabilities when exposed to low lipid environments
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-4154
Abstract: Cancer cell metabolism is significantly influenced by microenvironmental factors such as nutrient availability, which can vary across different tissues and introduce exploitable therapeutic vulnerabilities. Notably, lipid availability is particularly low in the brain compared to… read more here.
Keywords: cancer; cancer cells; lipid depleted; low lipid ... See more keywords
IDENTIFICATION OF TARGET GENES FOR NOVEL METABOLIC STRATEGIES IN THE TREATMENT OF RENAL TUMORS
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DOI: 10.15407/oncology.2024.04.275
Abstract: Summary. Aim: to identify genes encoding metabolic enzymes downregulated in various types of renal tumors, aiming to develop novel metabolic therapeutic strategies for renal cancer treatment. Object and methods: twenty pairs of clear cell renal… read more here.
Keywords: treatment; metabolic strategies; strategies renal; cell ... See more keywords
Prospective Association of Novel Metabolic Indices with Metabolic Syndrome in Middle-Aged and Elderly Chinese
Sign Up to like & getrecommendations! Published in 2021 at "Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy"
DOI: 10.2147/dmso.s288081
Abstract: 1Department of Metabolism and Endocrinology, The First Affiliated Hospital of University of South China, Hengyang, 421001, Hunan Province, People’s Republic of China; 2Institute of Endocrine and Metabolic Diseases, The First Affiliated Hospital of University of… read more here.
Keywords: metabolic syndrome; prospective association; novel metabolic; association novel ... See more keywords
The Nonlinear Correlation Between a Novel Metabolic Score for Insulin Resistance and Subclinical Myocardial Injury in the General Population
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.889379
Abstract: Background Growing studies have shown that insulin resistance (IR) is associated with cardiovascular disease (CVD), while the association between IR and subclinical myocardial injury (SC-MI) remains unclear. Hence we aimed to assess the association between… read more here.
Keywords: metabolic score; myocardial injury; novel metabolic; subclinical myocardial ... See more keywords