6-Aryl Isoindolin-1-ones: Novel mGluR2 Negative Allosteric Modulators.
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DOI: 10.1021/acsmedchemlett.5c00106
Abstract: This highlight presents novel 6-aryl isoindolin-1-one derivatives that developed as negative allosteric modulators (NAMs) of metabotropic glutamate receptor 2 (mGluR2). Chemical synthesis and potency (IC50) data for both mGluR2 and mGluR3 are disclosed. read more here.
Keywords: allosteric modulators; negative allosteric; aryl isoindolin; ones novel ... See more keywords