Abstract 6239: PM534 is a novel microtubule-destabilizing agent with high affinity and potent antineoplastic properties
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DOI: 10.1158/1538-7445.am2023-6239
Abstract: Background: Microtubule targeting compounds are a successful class of anticancer agents in the clinic. Although highly potent, the currently approved antitumor agents targeting tubulin present some drawbacks such as the development of acquired resistances, which… read more here.
Keywords: microtubule destabilizing; high affinity; affinity; novel microtubule ... See more keywords
Recent Approaches to the Identification of Novel Microtubule-Targeting Agents
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DOI: 10.3389/fmolb.2022.841777
Abstract: Microtubules are key components of the eukaryotic cytoskeleton with essential roles in cell division, intercellular transport, cell morphology, motility, and signal transduction. They are composed of protofilaments of heterodimers of α-tubulin and β-tubulin organized as… read more here.
Keywords: microtubule targeting; novel microtubule; microtubule; identification novel ... See more keywords
Corrigendum: A Novel Microtubule-Tau Association Enhancer and Neuroprotective Drug Candidate: Ac-SKIP
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2021.687301
Abstract: [This corrects the article DOI: 10.3389/fncel.2019.00435.]. read more here.
Keywords: tau association; corrigendum novel; novel microtubule; enhancer neuroprotective ... See more keywords