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Published in 2020 at "Drug discovery today"
DOI: 10.1016/j.drudis.2020.09.027
Abstract: Statements, such as 'you need to break free from amide-formations to improve molecular properties' and 'novel chemistry leads to novel biology' are frequently encountered in the medicinal chemistry community. To verify whether truth lies in…
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Keywords:
easy chemistry;
complex diverse;
chemistry;
novel molecules ... See more keywords
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Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.1057083
Abstract: The phosphodiesterase (PDE) enzymes, key regulator of the cyclic nucleotide signal transduction system, are long-established as attractive therapeutic targets. During investigation of trends within clinical trials, we have identified a particularly high number of clinical…
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Keywords:
novel molecules;
pde inhibitors;
clinical trials;
development ... See more keywords
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Published in 2023 at "Molecules"
DOI: 10.3390/molecules28031224
Abstract: Uncontrolled proliferative signals and cell cycle dysregulation due to genomic or functional alterations are important drivers of the expansion of undifferentiated blast cells in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) cells. Therefore,…
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Keywords:
novel molecules;
cycle;
acute;
signals cell ... See more keywords