Can 'easy' chemistry produce complex, diverse, and novel molecules?
Sign Up to like & getrecommendations! Published in 2020 at "Drug discovery today"
DOI: 10.1016/j.drudis.2020.09.027
Abstract: Statements, such as 'you need to break free from amide-formations to improve molecular properties' and 'novel chemistry leads to novel biology' are frequently encountered in the medicinal chemistry community. To verify whether truth lies in… read more here.
Keywords: easy chemistry; complex diverse; chemistry; novel molecules ... See more keywords
Thyromimetics and MASLD: Unveiling the Novel Molecules Beyond Resmetirom
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Gastroenterology and Hepatology"
DOI: 10.1111/jgh.16874
Abstract: Resmetirom, the first FDAâapproved drug for nonalcoholic steatohepatitis (NASH) with fibrosis in obese patients, when combined with lifestyle modifications, improves NASH resolution and reduces fibrosis by at least one stage. Low thyroid hormone (T3) levels… read more here.
Keywords: thyromimetics masld; novel molecules; masld unveiling; unveiling novel ... See more keywords
Recent developments of phosphodiesterase inhibitors: Clinical trials, emerging indications and novel molecules
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.1057083
Abstract: The phosphodiesterase (PDE) enzymes, key regulator of the cyclic nucleotide signal transduction system, are long-established as attractive therapeutic targets. During investigation of trends within clinical trials, we have identified a particularly high number of clinical… read more here.
Keywords: novel molecules; pde inhibitors; clinical trials; development ... See more keywords
Novel Molecules in Diabetes Mellitus, Dyslipidemia and Cardiovascular Disease 2.0
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DOI: 10.3390/ijms25179527
Abstract: Diabetes mellitus, dyslipidemia and cardiovascular disorders represent very prevalent chronic diseases in developed countries contributing to a high morbidity and loss of quality of life [...]. read more here.
Keywords: novel molecules; dyslipidemia cardiovascular; diabetes mellitus; molecules diabetes ... See more keywords
Targeting Proliferation Signals and the Cell Cycle Machinery in Acute Leukemias: Novel Molecules on the Horizon
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DOI: 10.3390/molecules28031224
Abstract: Uncontrolled proliferative signals and cell cycle dysregulation due to genomic or functional alterations are important drivers of the expansion of undifferentiated blast cells in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) cells. Therefore,… read more here.
Keywords: novel molecules; cycle; acute; signals cell ... See more keywords