A novel mouse model of upper tract urothelial carcinoma highlights the impact of dietary intervention on gut microbiota and carcinogenesis prevention despite carcinogen exposure
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Cancer"
DOI: 10.1002/ijc.35295
Abstract: Animal models of N‐butyl‐N‐(4‐hydroxy butyl) nitrosamine (BBN)‐induced urothelial carcinoma (UC), particularly bladder cancer (BC), have long been established. However, the rare incidence of BBN‐induced upper urinary tract UC (UTUC), which originates from the same urothelium… read more here.
Keywords: urothelial carcinoma; novel mouse; mouse model; tract ... See more keywords
A novel mouse model overexpressing Nocturnin results in decreased fat mass in male mice
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28623
Abstract: Nocturnin (NOCT) belongs to the Mg2+ dependent Exonucleases, Endonucleases, Phosphatase (EEP) family of enzymes that exhibit various functions in vitro and in vivo. NOCT is known to function as a deadenylase, cleaving poly‐A tails from… read more here.
Keywords: male mice; novel mouse; fat mass;
Behavioral and neurobiological changes in a novel mouse model of schizophrenia induced by the combination of cuprizone and MK-801
Sign Up to like & getrecommendations! Published in 2021 at "Brain Research Bulletin"
DOI: 10.1016/j.brainresbull.2021.06.007
Abstract: Schizophrenia is a mental illness characterized by episodes of psychosis, apathy, social withdrawal, and cognitive impairment. White matter lesions and glutamatergic hypofunction are reported to be the key pathogeneses underlying the multiple clinical symptoms of… read more here.
Keywords: novel mouse; schizophrenia; cuprizone; model ... See more keywords
A novel mouse strain optimized for chronic human antibody administration
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2123002119
Abstract: Significance Species differences in IgG Fc–Fcγ receptor (FcγR) interactions have made humanized mouse models an attractive strategy to evaluate the efficacy and toxicity of human antibodies. We previously published a humanized FcγR mouse model that… read more here.
Keywords: human igg; administration; mouse strain; mouse ... See more keywords
A novel mouse model of CMT1B identifies hyperglycosylation as a new pathogenetic mechanism
Sign Up to like & getrecommendations! Published in 2022 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddac170
Abstract: Abstract Mutations in the Myelin Protein Zero gene (MPZ), encoding P0, the major structural glycoprotein of peripheral nerve myelin, are the cause of Charcot–Marie-Tooth (CMT) type 1B neuropathy, and most P0 mutations appear to act… read more here.
Keywords: cmt1b; glycosylation; model; novel mouse ... See more keywords
Cenupatide is an effective antiangiogenic in a novel mouse model of rubeosis iridis associated with neovascular glaucoma
Sign Up to like & getrecommendations! Published in 2018 at "Acta Ophthalmologica"
DOI: 10.1111/aos.13972_11
Abstract: Peripheral ischemia in diabetic retinopathy (DR) is a sight threatening condition especially in the presence of disc or preretinal neovessels. Based on the ETDRS studies, peripheral laser photocoagulation (PRP) has been recognized for more than… read more here.
Keywords: cenupatide effective; novel mouse; effective antiangiogenic; ischemia ... See more keywords
Novel mouse model for cholestasis‐induced liver fibrosis resolution by cholecystojejunostomy
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Gastroenterology and Hepatology"
DOI: 10.1111/jgh.15406
Abstract: Studies on the resolution of liver fibrosis are becoming more important in this era of etiologic eradication. In contrast to the extensive research on the recovery of liver fibrosis induced by hepatotoxic injuries, regression of… read more here.
Keywords: model cholestasis; novel mouse; fibrosis; liver fibrosis ... See more keywords
A novel mouse model for investigating α-synuclein aggregates in oligodendrocytes: implications for the glial cytoplasmic inclusions in multiple system atrophy
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Brain"
DOI: 10.1186/s13041-024-01104-7
Abstract: The aggregated alpha-synuclein (αsyn) in oligodendrocytes (OLGs) is one of the pathological hallmarks in multiple system atrophy (MSA). We have previously reported that αsyn accumulates not only in neurons but also in OLGs long after… read more here.
Keywords: system atrophy; novel mouse; syn aggregates; multiple system ... See more keywords
Role of a novel mouse mutant of the Galnt2tm1Lat/tm1Lat gene in otitis media
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2022.1054704
Abstract: Genetic susceptibility is one of the most important causes of otitis media (OM). Mutant Galnt2 homozygote (Galnt2 tm1Lat/tm1Lat) mimics human otitis media in comparable pathology and causes hearing loss. Otitis media is characterized by effusion… read more here.
Keywords: middle ear; mouse; otitis media; mouse mutant ... See more keywords
Establishment of a Novel Mouse Hepatocellular Carcinoma Model for Dynamic Monitoring of Tumor Development by Bioluminescence Imaging
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.794101
Abstract: In this study, a novel mouse model of hepatocellular carcinoma (HCC) was established by simultaneously knocking out Pten and p53 suppressor genes and overexpressing c-Met and △90-β-catenin proto-oncogenes in the livers of mice via hydrodynamic… read more here.
Keywords: novel mouse; hepatocellular carcinoma; model; bioluminescence imaging ... See more keywords
Re-evaluation of neuronal P2X7 expression using novel mouse models and a P2X7-specific nanobody
Sign Up to like & getrecommendations! Published in 2018 at "eLife"
DOI: 10.7554/elife.36217
Abstract: The P2X7 channel is involved in the pathogenesis of various CNS diseases. An increasing number of studies suggest its presence in neurons where its putative functions remain controversial for more than a decade. To resolve… read more here.
Keywords: p2x7 specific; novel mouse; specific nanobody; p2x7 ... See more keywords