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Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28623
Abstract: Nocturnin (NOCT) belongs to the Mg2+ dependent Exonucleases, Endonucleases, Phosphatase (EEP) family of enzymes that exhibit various functions in vitro and in vivo. NOCT is known to function as a deadenylase, cleaving poly‐A tails from…
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Keywords:
male mice;
novel mouse;
fat mass;
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Published in 2021 at "Brain Research Bulletin"
DOI: 10.1016/j.brainresbull.2021.06.007
Abstract: Schizophrenia is a mental illness characterized by episodes of psychosis, apathy, social withdrawal, and cognitive impairment. White matter lesions and glutamatergic hypofunction are reported to be the key pathogeneses underlying the multiple clinical symptoms of…
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Keywords:
novel mouse;
schizophrenia;
cuprizone;
model ... See more keywords
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Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2123002119
Abstract: Significance Species differences in IgG Fc–Fcγ receptor (FcγR) interactions have made humanized mouse models an attractive strategy to evaluate the efficacy and toxicity of human antibodies. We previously published a humanized FcγR mouse model that…
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Keywords:
human igg;
administration;
mouse strain;
mouse ... See more keywords
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1
Published in 2022 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddac170
Abstract: Abstract Mutations in the Myelin Protein Zero gene (MPZ), encoding P0, the major structural glycoprotein of peripheral nerve myelin, are the cause of Charcot–Marie-Tooth (CMT) type 1B neuropathy, and most P0 mutations appear to act…
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Keywords:
cmt1b;
glycosylation;
model;
novel mouse ... See more keywords
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Published in 2018 at "Acta Ophthalmologica"
DOI: 10.1111/aos.13972_11
Abstract: Peripheral ischemia in diabetic retinopathy (DR) is a sight threatening condition especially in the presence of disc or preretinal neovessels. Based on the ETDRS studies, peripheral laser photocoagulation (PRP) has been recognized for more than…
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Keywords:
cenupatide effective;
novel mouse;
effective antiangiogenic;
ischemia ... See more keywords
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Published in 2021 at "Journal of Gastroenterology and Hepatology"
DOI: 10.1111/jgh.15406
Abstract: Studies on the resolution of liver fibrosis are becoming more important in this era of etiologic eradication. In contrast to the extensive research on the recovery of liver fibrosis induced by hepatotoxic injuries, regression of…
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Keywords:
model cholestasis;
novel mouse;
fibrosis;
liver fibrosis ... See more keywords
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2
Published in 2023 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2022.1054704
Abstract: Genetic susceptibility is one of the most important causes of otitis media (OM). Mutant Galnt2 homozygote (Galnt2 tm1Lat/tm1Lat) mimics human otitis media in comparable pathology and causes hearing loss. Otitis media is characterized by effusion…
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Keywords:
middle ear;
mouse;
otitis media;
mouse mutant ... See more keywords
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Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.794101
Abstract: In this study, a novel mouse model of hepatocellular carcinoma (HCC) was established by simultaneously knocking out Pten and p53 suppressor genes and overexpressing c-Met and △90-β-catenin proto-oncogenes in the livers of mice via hydrodynamic…
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Keywords:
novel mouse;
hepatocellular carcinoma;
model;
bioluminescence imaging ... See more keywords
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Published in 2018 at "eLife"
DOI: 10.7554/elife.36217
Abstract: The P2X7 channel is involved in the pathogenesis of various CNS diseases. An increasing number of studies suggest its presence in neurons where its putative functions remain controversial for more than a decade. To resolve…
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Keywords:
p2x7 specific;
novel mouse;
specific nanobody;
p2x7 ... See more keywords