Discovery of novel mRNA demethylase FTO inhibitors against esophageal cancer
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2022.2098954
Abstract: Abstract A series of 1,2,3-triazole analogues as novel fat mass and obesity-associated protein (FTO) inhibitors were synthesised in this study. Among all 1,2,3-triazoles, compound C6 exhibited the most robust inhibition of FTO with an IC50… read more here.
Keywords: discovery novel; esophageal cancer; fto; novel mrna ... See more keywords
A Novel mRNA Modification Mutation in a Patient With Ligneous Conjunctivitis Coexisting With Heterozygous Familial Mediterranean Fever Mutation.
Sign Up to like & getrecommendations! Published in 2021 at "Cornea"
DOI: 10.1097/ico.0000000000002702
Abstract: PURPOSE To describe a novel mRNA mutation associated with ligneous conjunctivitis (LC) in a patient with heterozygous familial Mediterranean fever (FMF) mutation. METHODS Case presentation of a patient with LC and heterozygous FMF mutation. The… read more here.
Keywords: patient; novel mrna; mediterranean fever; ligneous conjunctivitis ... See more keywords
A novel mRNA vaccine, SYS6006, against SARS-CoV-2
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1051576
Abstract: The development of vaccines that can efficiently prevent the infection of SARS-CoV-2 is necessary to fight the COVID-19 epidemic. mRNA vaccine has been proven to induce strong humoral and cellular immunity against SARS-CoV-2. Here, we… read more here.
Keywords: vaccine; vaccine sys6006; novel mrna; mrna vaccine ... See more keywords