Identification of novel MRP3 inhibitors based on computational models and validation using an in vitro membrane vesicle assay
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DOI: 10.1016/j.ejps.2017.02.011
Abstract: Introduction: Multidrug resistance‐associated protein 3 (MRP3), an efflux transporter on the hepatic basolateral membrane, may function as a compensatory mechanism to prevent the accumulation of anionic substrates (e.g., bile acids) in hepatocytes. Inhibition of MRP3… read more here.
Keywords: inhibition; novel mrp3; mrp3; model ... See more keywords